Design and optimization of immediate release tablet of salbutamol sulphate by direct compression technique
DOI:
https://doi.org/10.18231/2348-0335.2018.0010Keywords:
Salbutamol Sulphate, immediate release drug delivery system, immediate release tablet, super disintegrantAbstract
This study is about a tablet, which disintegrates or dissolves quickly when placed in the oral cavity. Studies on formulation development of Salbutamol Sulphate Immediate Release Tablet, suitable for manufacturing by direct compression have been carried out. Trial formulations using various excipients were developed and evaluated for various qualities like hardness, friability, disintegration time, content uniformity and dissolution. Study concluded that Immediate Release Tablet of Salbutamol Sulphate can be prepared successfully with added patient benefit and increased consumer satisfaction.
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References
Slowson M and Slowson S. What to do when patients cannot swallow their medications. Pharma Times, 51, 90‐96 (1985)
Indurwade NH, Rajyaguru TH and Nakhat PD. Novel approach: Fast dissolving tablets. Indian Drugs, 39(8), 405‐41 (2002)
Seager HJ. Drug delivery products and zydis fast dissolving dosage forms. Pharm Pharmcol, 50:375‐382 (1998)
Gohel M, Patel M, Amin A, Agrawal R, Dave R and Bariya N. Formulation design and optimization of mouth dissolve tablets of nimesulide using vacuum drying technique. AAPS Pharm Sci Tech, 5, 36 (2004)
Reddy LH, Ghosh B and Rajneesh. Fast dissolving drug delivery system: A review of literature. Indian J Pharm Sci, 64 (4), 331‐336 (2002)
Habib W, Khankari R and Hontz J. Fast‐dissolving drug delivery systems: Critical review in therapeutics. Drug Carrier Systems, 17(1), 61‐72 (2002)
Biradar SS, Bhagavati ST and Kuppasad IJ. Fast dissolving drug delivery systems: A brief overview. The Int J Pharmacol, 4(2). (2006)
Bhaskaran S, Narmada GV. Rapid Dissolving tablet A Novel dosage form. Indian Pharmacist, 1, 9‐12 (2002)
Devrajan PV and Gore SP, Melt‐ in‐ mouth tablets: innovative oral drug delivery system. Express Pharma Pulse, 7(1), 16 (2000)
Bolhius GK, Zuurman K and Te‐Wierik GH. Improvement of dissolution of poorly soluble drugs by solid deposition on a superdisintegrant. Part 2. Choice of super disintegrants and effect of granulation. Eur J Pharm Sci, 5(2), 63–69 (1997)
Kuchekar BS, Badhan CA and Mahajan HS. Mouth dissolving tablets: A novel drug delivery system. Pharma Times, 35, 7‐10 (2003)
Yarwood RJ, Kearny P and Thomson AR. Process for preparing solid pharmaceutical dosage forms. US Patent No. 5738875 (1998)
Mizumoto T, Masuda Y and Fukui M. Intrabuccally dissolving compressed moldings and production process thereof. US Patent No. 5576014 (1996)
Kaushik D, Dureja H and Saini TR. Mouth dissolving tablets: A Review. Indian Drugs, 41(4),187‐192 (2004)
Gole DJ, Levinson RS and Carbone J. Preparation of pharmaceutical and other matrix systems by solid state dissolution. US Patent, No. 5215756 (1993)
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