Journal of Applied Pharmaceutical Research https://japtronline.com/index.php/joapr <p><em><strong>Journal of Applied Pharmaceutical Research (JOAPR),</strong> <strong>ISSN No. 2348-0335</strong></em> is an official publication of Creative Pharma Assent (CPA). It is an open access, peer reviewed online Journal. JOAPR primarily focuses on publication of manuscript related to multiple disciplines of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy). JOAPR is published quarterly. JOAPR also includes evaluation of pharmaceutical excipients &amp; their practical application to research &amp; industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publishes original research works with a definite innovation and novelty after thorough plagiarism checking and peer reviewing. The paper must have a suitable and proper scientific background.</p> <p><strong>Brief Information about JOAPR</strong></p> <ul> <li><strong>Journal Title: </strong>Journal of Applied Pharmaceutical Research</li> <li><strong>Journal Abbreviation: </strong>J. Appl. Pharm. Res.</li> <li><strong>Publisher: </strong>Creative Pharma Assent</li> <li><strong>Country: </strong>India</li> <li><strong>Language: </strong>English</li> <li><strong>Publishing Frequency: </strong>Quarterly</li> <li><strong>Editor In Chief:</strong> Prof. Amit Roy</li> <li><strong>Editorial Office: </strong>Plot No. 105/42, Opposite electricity sub station, Changorabhata, Raipur (CG) 492001, India</li> <li><strong>Regional Office:</strong> Bishnupath, Rukminigoan, Dispur, Guwahati, Assam, PIN-781022</li> <li><strong>Phone: </strong>+91-8349444385 ; +91-9770019143</li> <li><strong>E-mail: </strong>editor@japtronline.com ; japr.editor@gmail.com</li> <li><strong>Website: </strong>https://www.japtronline.com</li> <li><strong>Publication: </strong>Online only</li> <li><strong>e-ISSN: </strong>2348-0335</li> <li><strong>CODEN: </strong>JAPRIV</li> <li><strong>Year of Start: </strong>2013</li> <li><strong>Review Process</strong><strong>: </strong>Double-blind peer review</li> </ul> Creative Pharma Assent en-US Journal of Applied Pharmaceutical Research 2348-0335 <p>In submitting an article to Journal of Applied Pharmaceutical Research (JOAPR) I certify that:</p> <ol> <li>I am authorized by my co-authors to enter into these arrangements.</li> <li>I warrant, on behalf of myself and my co-authors, that:</li> </ol> <ul> <li>the article is original, has not been formally published in any other peer-reviewed journal, is not under consideration by any other journal and does not infringe any existing copyright or any other third party rights;</li> <li>I am/we are the sole author(s) of the article and have full authority to enter into this agreement and in granting rights to JOAPR are not in breach of any other obligation;</li> <li>the article contains nothing that is unlawful, libellous, or which would, if published, constitute a breach of contract or of confidence or of commitment given to secrecy;</li> <li>I/we have taken due care to ensure the integrity of the article. To my/our - and currently accepted scientific - knowledge all statements contained in it purporting to be facts are true and any formula or instruction contained in the article will not, if followed accurately, cause any injury, illness or damage to the user.</li> </ul> <ol> <li>I, and all co-authors, agree that the article, if editorially accepted for publication, shall be licensed under the <a href="http://creativecommons.org/licenses/by-nc/4.0/">Creative Commons Attribution-NonCommercial 4.0 International License</a></li> <li>I, and all co-authors, agree that, if the article is editorially accepted for publication in Journal of Applied Pharmaceutical Research (JOAPR) data included in the article shall be made available under the <a href="http://creativecommons.org/publicdomain/zero/1.0/legalcode">Creative Commons 1.0 Public Domain Dedication waiver</a>, unless otherwise stated. For the avoidance of doubt it is stated that sections 1, 2, and 3 of this license agreement shall apply and prevail.</li> </ol> Overview of formulation & evaluation of fast dissolving tablet: A promising tablet dosage form https://japtronline.com/index.php/joapr/article/view/134 <p>The science of drug delivery has been increasingly innovative and quick evolving with ever-increasing demand in the current scientific scenario. Fast dissolving tablet (FDT) is one of those forms of an advanced and special drug delivery system that is rapidly gaining a lot of attention in the rapid dissolution technology research sector.</p> <p>Fast dissolving tablets appear as one of the common and widely accepted dosage types, particularly for paediatric patients due to incomplete muscle and nervous system development and a form of geriatric patients with Parkinson's disease or hand shivering. The most popular administrative path for different medications has drawbacks such as first-pass metabolism, psychotic patients, bedridden and Uncollaborative patients, is the oral delivery type and oral path FDTs disintegrate or quickly dissolve in the saliva without requiring water. Within few seconds, FDT will dissolve within saliva for approximately 60 seconds and these comprises will dissolve even faster</p> Akash Babu Md. Semimul Akhtar Copyright (c) 2020 Akash Babu, Md. Semimul Akhtar https://creativecommons.org/licenses/by-nc/4.0 2020-08-31 2020-08-31 8 3 01 09 10.18231/j.joapr.2020.v.8.i.3.1.9 A review on novel COVID-19: background, etiology, pathogenesis, transmission, prevention and management https://japtronline.com/index.php/joapr/article/view/170 <p>Mankind's history is watching a bizarre time battling an imperceptible adversary, the novel COVID-19 Coronavirus. At first seen in the Wuhan province of China, presently limitlessly spreading all over world. How the COVID 19 has been made on the globe become Pandemic needs no depiction. The virus has been accounted for affecting the lungs and related respiratory tracts promoting harm of the alveoli. It has been accounted that the respiratory sickness is the prevailing Clinical symptom of COVID-19. This review article discusses an easily understanding of the causes, different type of Human viruses regarded of Coronavirus, clinical diagnosis of RT-PCR, FET, Primary prevention and control of the virus. Therefore, this review article main theme is to provide more reliable and valid information to control and manage public emergency in both acute and chronic conditions of coronavirus</p> Kalyani. R Padmasri B. Anilkumar V. Prasanth. D. Copyright (c) 2020 https://creativecommons.org/licenses/by-nc/4.0 2020-08-31 2020-08-31 8 3 10 20 10.18231/j.joapr.2020.v.8.i.3.10.20 Traditional and medicinal use of Barbaloin: potential for the management of various diseases https://japtronline.com/index.php/joapr/article/view/139 <p>Barbaloin is the phytoconstituent which is obtained from the plant known as <em>aloe vera</em>. As we all know <em>aloe vera</em> is the main curative medicinal plants, has been traditionally used as alternative treatment against the many skin diseases. Barbaloin extracted from the <em>aloe vera</em> plant which is physically light yellow colored powder. Extraction of barbaloin from the plant <em>Aloe barbadensis Miller</em> had been accomplished by the Soxhelt extraction, Batch extraction experiment and Ultrasound assisted extraction method (UAE). Barbaloin showed various kinds of therapeutic and medicinal properties like anti-diabetic, antioxidants, anti-cancer, anti-inflammatory and and anti-microbial. It also has good effect on cardiovascular system, test perception, enzyme or metabolism and bioavailability. Our Skin plays an important role in the development of skin diseases because there are many types of skin disorders are developed and the variety of disorders may result to dermatitis or they affect the social wellbeing of a person. Due to their good pharmacological activities, Barbaloin have great potential to treat the different type of skin disorders like Eczema, Psoriasis, Burns and wound, Acne, Dandruff, Frostbite, Rashes, Cold sores, Razor burn and Sunburn. To access the effective use of barbaloin there are various attempts have been experimented on the subject of their Pharmacological activities to check their effect on skin disease and the steps regarding the Isolation of barbaloin also has been made. We can examine their effects on chronic skin diseases. In this review article we discuss about the potential of barbaloin on skin disorders, medicinal importance or Pharmacological activities and their methods of extraction.</p> Navdeep Singh Kamya Goyal Shivi Sondhi Shammy Jindal Copyright (c) 2020 Navdeep Singh, Kamya Goyal, Shivi Sondhi, Shammy Jindal https://creativecommons.org/licenses/by-nc/4.0 2020-08-31 2020-08-31 8 3 21 30 10.18231/j.joapr.2020.v.8.i.3.21.30 A review on characteristics and analytical methods of atovaquone – a potent antimalarial agent https://japtronline.com/index.php/joapr/article/view/140 <p>Drugs used in the treatment of malaria that is caused by various plasmosium species i.e. <em>P. falciparum, P. vivax</em> are most irresistible disease throughout the world. The different medications are utilized in the treatment of malaria incorporated the Aryl aminoalcohol mixes: Quinine, Quinidine, Chloroquine, Mefloquine; Antifolate compound: Pyrimethamine, Proguanil, Chlorproguanil, Trimethoprim and Atovaquone. Atovaquone is most effective drug utilized in the treatment of malaria. It must be given in single or in mixture with different antimalarials. An enormous number of methodologies including High Performance Liquid chromatography (HPLC), UV–Visible spectroscopy and Liquid Chromatography-Mass Spectroscopy (LC-MS) are utilized for the determination of atovaquone. Various analytical methods are used for the analysis of pharmaceutical products and these methods were validated according to ICH guidelines (Q1A R2). Thus, this technique can be safely used for the standard quality control analysis of atovaquone.</p> Sanyam Sharma Rahul Sharma Arti Devi Shammy Jindal Kamya Goyal Copyright (c) 2020 Sanyam Sharma, Rahul Sharma, Arti Devi, Shammy Jindal, Kamya Goyal https://creativecommons.org/licenses/by-nc/4.0 2020-08-31 2020-08-31 8 3 31 37 10.18231/j.joapr.2020.v.8.i.3.31.37 Method development and validation of aspirin and clopidogrel pharmaceutical dosage forms by developing new RP HPLC method https://japtronline.com/index.php/joapr/article/view/127 <p>A simple and selective LC method is described for the determination of Aspirin and Clopidogrel in tablet dosage forms. Chromatographic separation was achieved on a c18 column along with mobile phase consisting of a combination of fifty five volumes of Mixed Phosphate Buffer and forty five volumes of Acetonitrile with detection of 235 nm. Linearity was observed in the range 20-60 μg/ml for Aspirin (r2=0.998) and 10-30 μg /ml for Clopidogrel (r2 =0.998) for the amount of drugs estimated by the projected ways was in smart agreement with the label claim. The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD trials. All statistical data proves validity of the ways and may be used for routine analysis of pharmaceutical dosage form.</p> Nellore Dharani Sai Sreekanth Nenavath Adilakshmi Copyright (c) 2020 Nellore Dharani Sai Sreekanth, Nenavath Adilakshmi https://creativecommons.org/licenses/by-nc/4.0 2020-08-31 2020-08-31 8 3 38 47 10.18231/j.joapr.2020.v.8.i.3.38.47 Development and validation of novel method for simultaneous estimation of Atovaquone and Mefloquine hydrochloride in bulk drug using RP-HPLC https://japtronline.com/index.php/joapr/article/view/158 <p>Atovaquone and Mefloquine hydrochloride are well known anti-malarial drugs. Literature survey reveals that there was no method available for the selected drug combination. In this way, here an endeavour has been made to develop simple, precise, fast method for simultaneous estimation of atovaquone and mefloquine hydrochloride in bulk drug by using RP-HPLC method. The method was carried out by using gradient HPLC on C18 column using Shimadzu prominence LC 20 AD and mobile phase comprised of Methanol:ACN:Water in the ratio of 85:7.5:7.5 (pH 2.9 was adjusted with OPA). The method was performed with 10µl injection volume. The UV detection was done at 231nm.The retention times of atovaquone and mefloquine hydrochloride were 7.6 and 2.6 min respectively. The proposed method was validated according to ICH guidelines. The validation parameters were linearity, accuracy, precision (inter-day, intra-day and repeatability) and robustness etc. Linearity was in the range of 80-120µg/ml for atovaquone and 40-60µg/ml for mefloquine hydrochloride. The percent recoveries of both drugs were 99.99-100% and 92.05-99.09%. This method is suitable for the routine analysis of atovaquone and mefloquine hydrochloride in bulk drugs either individually or in mixture</p> Sanyam Sharma Amar Deep Ankalgi Rahul Sharma Arti Devi Shammy Jindal Kamya Goyal Copyright (c) 2020 Amar Deep Ankalgi, Sanyam Sharma, Rahul Sharma, Arti Devi, Shammy Jindal, Kamya Goyal https://creativecommons.org/licenses/by-nc/4.0 2020-08-31 2020-08-31 8 3 48 54 10.18231/j.joapr.2020.v.8.i.3.48.54 Phytochemical investigations of Campsis radicans L. https://japtronline.com/index.php/joapr/article/view/135 <p>Petroleum ether, dichloromethane and ethyl acetate soluble fractions were obtained through partitioning the crude methanolic extract of the leaves of <em>Campsis radicans</em> L. (Family. Bignoniaceae) followed by the chromatographic separation of secondary metabolites from them. A total of five triterpene compounds <em>i.e., </em>corosolic acid methyl ester (<strong>1</strong>), <em>β</em>-amyrin (<strong>2</strong>), arjunolic acid (<strong>3</strong>), maslinic acid (<strong>4</strong>) and 28-O-[<em>β</em>-D-glucopyranosyl-(1→6)-<em>β</em>-D-glucopyranosyl]-2<em>α</em>,3<em>α</em>,19<em>α</em>-trihydroxy-12-en-28-ursolic acid (<strong>5</strong>) were isolated from the dichloromethane fractions and their structures were characterized by <sup>1</sup>H NMR spectroscopy and compared the NMR data with published values.</p> Mirazul Islam Md Ruhul Kuddus Mohammad Abdur Rashid Mohammad Rashedul Haque Copyright (c) 2020 Mirazul Islam, Md Ruhul Kuddus, Mohammad Abdur Rashid, Mohammad Rashedul Haque https://creativecommons.org/licenses/by-nc/4.0 2020-08-31 2020-08-31 8 3 55 59 10.18231/j.joapr.2020.v.8.i.3.55.59