Review on natural gums and mucilage and their application as excipient
DOI:
https://doi.org/10.18231/2348-0335.2017.0010Keywords:
Natural gum, Mucilage, Natural polysaccharide, Pharmaceutical excipientAbstract
Natural mucilage’s are included in novel drug delivered (NDDS) to multitask functions and in any cases directly or indirectly control the increase and rate of drug release. Substantial research efforts have been directed towards develop safe and efficient natural based mucilage particulate drug delivery systems., natural gums and mucilages and their isolation, purification, standardization and characterization characteristics along with their applications are covered. Recent trend towards the use of plant based and natural products demands the replacement of synthetic additives with natural ones. Today, the whole world is increasingly interested in natural drugs and excipients. These natural mucilages have advantages over synthetic ones since they are chemically inert, nontoxic, less expensive, and widely available.
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References
Nilesh Jain, Ruchi Jain, Vaibhav Jain and Surendra Jain. A review on: Abelmoschus esculentus. Pharmacia, 1(3), 2012: 84-89
Umesh Kumar, M. Deogade, V. N. Deshmukh, D. M. Sakarkar. Natural Gums and Mucilage’s in NDDS: Applications and Recent approaches. International Journal of PharmTech Research, 4(2), 2012: 799-814
Geetha B, Gowda KPS and Kulkarni GT. Microwave assisted fast extraction of mucilages and pectins. Ind J Pharm Edu Res 2009, 43: 261-265.
M. R. Reddy, K. Manjunath. Pharmaceutical Applications of Natural Gums, Mucilages and Pectins - A Review. International Journal of Pharmaceutical and Chemical sciences, 2(3), 2013
Girish JK, Dhiren SP, Vipul PD and Vineet JC. Gums and mucilages: versatile excipients for pharmaceutical formulations. Asian J Pharm Sci 2009; 4:309-323.
Beneke, C.E., Viljoen, A. M., Hamman, J. H. Polymeric Plant-derived Excipients in Drug Delivery. Molecules. 2009; 14, 2602-2620
Pandey R., Khullar G. K. Polymer based drug delivery systems for mycobacterial infections. Cur. Drug Deli. 2001; 195-201.
Alosono-Sande M., Teijeiro D., Remunan-Lopez C., Alosono M.J. Glucomannan a promising polysaccharide for biopharmaceutical purpose. Euro. J. Pharm Biopharm . 2009; 72, 453-462
Kokate C. K., Purohit A. P., Gokhale, S. B. Pharmacognosy, Nirali Prakashan, Pune, India, 2006.
Rangari V. D. Pharmacognosy & Phytochemistry. Career Publication Nashik, India, 2006
Wallis T. E. Text Book of Pharmacognosy. CBS Publishers and Distributors, New Delhi, India,
Ali M. Text Book of Pharmacognosy. New Delhi,India: C B S Publishers and Distributors, 2005
Bharat W. Tekade, Yogita A. Chaudhari. Gums and Mucilages: Excipients for modified Drug Delivery System Journal of Advanced Pharmacy Education & Research. 3 (4), 2013: 359
Rangari V. D. Pharmacognocy and Phytochemistry. 2nd Ed, Published by career publications, 1: 190, 198, 191, 194, 193, 195.
Khandelwal K.R., Practical pharmacognosy techniques and experiment, 19th Ed. published by Nirali prakashan, 2008: 167,174,175,177,181
USP-NF, The official compendia of standers, Asian edition, 2008, 2: 1063, 1067,1261.
Kar A. Pharmacognocy and Pharmacobiotechnology, 2nd Ed, published by New Age International limited, publishers, 2007: 101,103,114,115.
Evans W.C. Treese and Evans Pharmacognocy.15th Ed., Published by Elsevier, 2007: 205,206,209.
Kumar T., Gupta S., Prajapati M., Tripathi D. K., et al. Natural Excipients: A Review. Asian Journal of Pharmacy and Life Science, 2012, 2 (1): 97-108.
Ramakrishnan A., Pandit N., Badgujar M., Bhaskar C., et al. Encapsulation of endoglucanase using a biopolymer gum arabic for its controlled release. Bioresource Technology. 2007, 98(2): 368-372.
Darekar Avinash Bhaskar, Kahane Jyoti Uttam, Ashawat Mahendra Singh, Chavan Machhindra Jayram, Saudagar Ravindranath Bhanudas. Plant Exudates and Mucilage as Pharmaceutical Excipients. Journal of Advanced Pharmacy Education & Research 3(4) 2013: 387
Rangari V.D. Pharmacognocy and Phytochemistry. 2nd Ed, Published by career publications,1: 190, 198, 191, 194, 193, 195
Anderson D.M., Bridgeman M.M. The composition of the proteinaceous polysaccharides exuded by astragalus microcephalus, A. Gummifer and A. Kurdicus -The sources of turkish gum tragacanth. Phytochemistry, 1985, 24(10): 2301-2304.
Evans W.C. Treese and Evans Pharmacognocy.15th Ed., Published by Elsevier, 2007: 205,206,209.
Raymond C. R., Paul J. S. and Sian C.O. Handbook of pharmaceutical excipient. 5th Ed. published by pharmaceutical press, 2006: 1,14,149,314,785,821.
Jain A, Gupta Y, Jain SK. Perspectives of Biodegradable Natural Polysaccharides for Site-Specific DrugDelivery to the Colon. J Pharm PharmaceutSci 2007; 10(1): 86-128.
Karan Malik, Gurpreet Arora, Inderbir Singh. Locust bean gum as superdisintegrant formulation and evaluation of nimesulide orodispersible tablets. Polymers in Medicine 2011; 17-28.
Venkatarajua MP, Gowdaa DV, Rajeshb KS, Shivakumara HG. Xanthan and locust bean gum (from Ceratoniasiliqua) matrix tablets for oral controlled delivery of propranolol hydrochloride. Asian J Pharm Sci 2007; 2(6): 239-48
Munday D. L., Philip. J. C. Compressed xanthan and karaya gum matrices: hydration, erosion and drug release mechanisms. International Journal of Pharmaceutics, 2000, 203(1-2): 179-192.
Reddy M.M., Reddy J.D., Moin A., Shivakumar H.G. Formulation of Sustained-Release Matrix Tablets Using Cross-linked Karaya Gum. Tropical Journal of Pharmaceutical Research, 2012, 11 (2): 185-192
Nadkarni K.M., Indian MateriaMedica. Published by Popular prakashan Pvt Ltd. Reprint 2007: 9,801,117
Deshmukh A.S., Setty C.M., Badiger A.M., Muralikrishna K.S. Gum ghatti: A promising polysaccharide for pharmaceutical applications. Carbohydrate Polymer, 2012, 87(2):980-986.
Maulesh G. Joshi, Setty C.M., Deshmukh A.S., Bhatt Y.A. Gum ghatti: A new release modifier for zero-order release in 3- layered tablets of diltiazem hydrochloride. Indian Journal of Pharmaceutical Education and Research, 2010, 44(1):78-8
Duke J.A. Handbook of medicinal herbs.2nd Ed, published by CRC press, 2002:4.
Baweja, J. M., Misra, A. N. Modified guar gum as film former. DiePharmazie, 1999, (9).
Baweja, J. M.; Misra, A. N. Modified guar gum as a tablet disintegrant. Die Pharmazie, 1997, 52(11):856- 859.
Datta R., Bandyopadhyay A.K. A new nasal drug delivery system for diazepam using natural mucoadhesive polysaccharide obtain from tamarind seed. Saudi Pharmaceutical Journal, 2006,14:115- 119
Basavaraj Someswara Rao B., Kulkarni S.V., Patil P. Design and Characterization of Sustained Release Aceclofenac Matrix Tablets Containing Tamarind Seed Polysaccharide. Asian Journal of Pharmacy and Technology 2011, 1( 1): 17-21
Zhang J., ShengjunXu., Shengtang Zhang., Zhaoli Du. Preparation and Characterization of Tamarind Gum/Sodium Alginate Composite Gel Beads. Iranian Polymer Journal, 2008,17 (12): 899-906
Kang K.S., Veeder G.T., Mirrasoul P.J., Kaneko.T., Cottrell I.W. Agar-like polysaccharide produced by pseudomonas species: production and basic properties, Applied and Environmental Microbiology. 1982, 43: 1086-1091.
Kuo. M.S., Mort. A.J., Dell. A. Identification and location of L-glycerate, an unusual acyl substituent in gellan gum, Carbohydrate Research. 1986, 156: 173-187
Miyazaki S., Aoyama H., Kawasaki N., Kubo W., Attwood D. In situ-gelling gellan formulations as vehicles for oral drug delivery. bJournal of Control Release 1999, 60 (2-3): 287-95
USP-NF, The official compendia of standers, Asian edition, 2008, 2: 1063, 1067, 1261
British pharmacopoeia. Published by B.P. Commission Office, (2009); 1: 37, 71, 978, 2661, 3557
Sharma B.R., Naresh L., Dhuldhoya N.C., Merchant S.U., Merchant U.C. Xanthan Gum - A Boon to Food Industry. Food Promotion Chronicle. 2006, 1(5): 27- 30
Santos S., Vegia F., Pina M.E., Sausa J.J. Compaction compression and drug release properties of diclofenac sodium and ibuprofen pellets comprising xanthan gum as a sustained release agent. International Journal of Pharmaceutics, 2005,296:1-11
Zawar L.R., Gupta A.J., Ige P.P., Bari S.B. Design and Development of Directly Compressed Sustained Release Matrix Tablets of Aceclofenac. Research Journal of Pharmacy and Technology, 2010, 3(1):168-174.
Datta R., Bandyopadhyay A.K. A new nasal drug delivery system for diazepam using natural mucoadhesive polysaccharide obtain from tamarind seed. Saudi pharmaceutical Journal, 2006, 14:115- 119.
Peter F.K., Alistair M.S., Shirley C.C. Molecular structures of gum exudates from hakea species. Phytochemistry 1999, 34(3):709-713.
Alur H.H., Pather S.I., Mitra A.K., Johnston T.P. Evaluation of the Gum from Hakea gibbosa as a Sustained-Release and Mucoadhesive Component in Buccal Tablets. Pharmaceutical Development and Technology 1999, 4(3): 347.
Attama A.A., Nwabunze O.J. Mucuna gum microspheres for oral delivery of glibenclamide: In vitro evaluation. Acta Pharmaceutica 2007, 57: 161– 171.
Kharwade R.S., Vyavhare N.S., More S.M. Formulation of mucoadhesive tablet by using Aegle marmelos gum. International Journal of applied Biology and Pharmaceutical Technology, 2011, 2(1):154-161
Patil D.N., Kulkarni A.R., Hatapakki B.C., Patil B.S. Preparation and Evaluation of Aegle marmelos Gum as Tablet Binder. International Journal of Pharma and Bio Sciences, 2010, 1(1):1-5.
Sharma P.C., Bhatia V., Bansal N., Sharma A. A Review on Bael tree. Natural Product Radiance, 2007, 6(2):171-178.
Dhiman B., Prashar B., ChandelA. Psyllium: A Potential carrier to control the drug delivery. International Research Journal of Pharmacy, 2012, 3(7):39-44.
Kalu V.D., Odeniyi M.A., Jaiyeoba K.T. Matrix properties of a new plant gum in controlled drug delivery. Archives of Pharmacal research, 2007, 30: 884-889
Ogaji I., Nnoli O. Film coating potential of okra gum using paracetamol tablets as a model drug. Asian Journal of Pharmaceutics, 2010, 4: 130-134.
Attama A.A., Adikwu M.U., Amorha C.J. Release of indomethacin from bioadhesive tablets containing Carbopol 941 modified with Abelmuschus esculentus (Okra) gum. Bollettino Chimico Farmaceutico, 2003, 142: 298-302.
Ogaji I. Some physicochemical properties of acetaminophen pediatric suspensions formulated with okra gums obtained from different extraction processes as suspending agent. Asian Journal of Pharmaceutics, 2011, 5: 15-20.
Chodavarapu N.P., Yendluri R.B., Suryadevara H. Formulation and evaluation of abelmoschus esculentus mucilage based metformin hydrochloride floating matrix tablets. International Journal of Pharmacy and Technology, 2011, 3 (2): 2725-2745.
Ilango K. B., Mishra M, Devi S., Rajsekaran A., Senthilkumar M. In vitro and In vivo evaluation of okra polysaccharide based colon targeted drug delivery systems. International Journal of Pharmaceutical Sciences Review and Research, 2010, 5(1):138-145.
Gangurde A. B., Malode S. S., Bhambar R. S. Preliminary Evaluation of Neem Gum as Tablet Binder. Indian Journal of Pharmaceutical Education & Research, 2008, 42(4): 344 – 347
Hindustan A.A., Chitta S. K., Anil Kumar B. Fabrication and evaluation of nimesulide Azadirachta indica fruit mucilage based sustained release matrix tablets. International Journal of ChemTech Research, 2010, 2(2): 937-941
Vazquez B, Avila G, Segura D, Escalante B. Anti inflammatory activity of extracts from Aloe vera gel. Journal of Ethnopharmacol, 1996, 55:69-75
Choi S., Chung M.H. A review on the relationship between Aloe vera components and their biologic effects. Seminars in Integrative Medicines, 2003, 1: 53-62
Hindustan A.A., Chitta S. K., Anil Kumar B,et al. Development and in vitro evaluation of glibenclamide Aloe barbadensis miller leaves mucilage controlled release matrix tablets. International Journal of Pharm Tech Research, 2010; 2 (2):1018-1021.
Jani G.K., Shah D.P., Jain V.C., Patel M.J., Vithalan D.A. Evaluating mucilage from Aloe barbadensis miller as a pharmaceutical excipient for sustained-release matrix tablets. Pharmaceutical Technology, 2007, 31:90-98.
The Wealth of India, First Supplement Series (Raw Materials), National Institute of Science and Communication, CSIR, New Delhi, India, 2002,5: H– K:91–92.
Jani G.K., Shah D.P. Assessing Hibiscus rosa-sinensis linn as an excipient in sustained-release tablets. Drug Development and Industrial Pharmacy, 2008, 34 (8):807 -16.
ShahV., Patel R. Studies on mucilage from Hibiscus rosa-sinensis Linn as oral disintegrant. International Journal of Applied Pharmaceutics, 2010, 2 (1):19-21.
Kritikar K.R., Basu B.D. Indian Medicinal Plants, 2nd Ed., International Book Distribution, Dehradun, India, 2006, 2:874.
Soni P.L., Pal R. Trends in Carbohydrate Chemistry, 1996, 2:33-44.
Singh S., Bothara S.B., Singh S., Patel R. D. Pharmaceutical characterization of Cassia tora of seed mucilage in tablet formulations. Scholars Research Library, 2010; 2(5): 54-61.
G.A. Petropoulos, “Fenugreek: The genus Trigonella,” in Botany, G. A. Petropoulus, Ed., pp. 9–17, Taylor & Francis, London, UK, 2002.
N. Ali, N. Hossein, K. Afagh, S. Tarifeh, V. Hadi, and J. L. Ford. An in vitro evaluation of fenugreek mucilage as a potential excipient for oral controlled-release matrix tablet. Drug Development and Industrial Pharmacy 34 (3), 2008: 323–329
R. N. Chopra, S. L. Nayar, and I. C. Chopra, Glossary of Indian Medicinal Plants, 1st edition, 1956.
Dinda S.C., Mukharjee B. Gum cordia – A new tablet binder and emulsifier. Acta Pharmaceutica Sciencia 2009; 51: 189- 198.
Girish K Jani, Dhiren P Shah, Vipul D Prajapatia, Vineet C Jain. Gums and mucilages: versatile excipients for pharmaceutical formulations. Asian Journal of Pharmaceutical Sciences 2009, 4 (5): 308-322
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