Synthesis and antifungal activity screening of some novel 7–substituted –2–hydroxy–quinoline schiff bases

M. R. Pradeep Kumar

Authors

M. R. Pradeep Kumar Department of Pharmaceutical Chemistry, KLEU’s College of Pharmacy, Hubli – 580031, Karnataka

Keywords:

Quinoline, antifungal, two fold dilution, fluconazole, Schiff base

Abstract

With an objective of synthesizing some novel, potent and broad spectrum antifungal activity having compounds, here some novel quinoline derivatives are reported. Initially 7-substituted-2-cholro-3-formylquinolines were prepared using well known Vilsemeir-Hack reagent method. These on microwave irradiation with 4M HCl yielded 7-substituted-2-hydroxy quinoline-3-carbaldehydes I(a, b), which on further treatment with different substituted hydrazides yielded the novel Schiff bases of quinoline II(a-f). The structure of all newly synthesized compounds was confirmed by spectral study such as IR, ¹H NMR, ¹³C NMR and mass spectroscopy. All the synthesized compounds were screened for in-vitro antifungal activity by two fold serial dilution method using fluconazole as the standard drug. Compounds II a, II b and II d showed significant antioxidant activity

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