Phytochemical and antipyretic potential of ethanolic leaf extract of Heliotropium indicum l.
In the present study, the ethanolic leaf extract of Heliotropium indicum L (H. indicum L) was investigated for phytochemical screening and antipyretic activity in rats using Brewer's yeast induced Pyrexia. The leaves of H. indicum were collected from different part of Assam and cut into small pieces and shade dried. The dried powdered leaves (100 gm) were extracted in a Soxhlet apparatus by using 95% ethanol. Phytochemical screening has been done by standard procedure and showed the presence of alkaloids, glycoside, carbohydrate, phytosterol, flavonoids and saponins and absence of fixed oil and gums-mucilage. Albino rats weighing (200-250g) were taken for the experiment divided into four groups of six animals each. Group 1 received 3% aqueous suspension of gum Acacia (1ml/200g) as vehicle orally, group 2 and group 3 received ethanolic leaf extract of H. indicum 250 and 500 mg/kg with 3% aqueous suspension of gum Acacia orally and the group 4 served as standard received paracetamol 25 mg/kg with 3% aqueous suspension of gum Acacia orally. The subcutaneous injection of yeast suspension markedly elevated the rectal temperature after 18h of administration. Treatment with H. indicum extract at a dose of 250, 500 mg/kg decreased the rectal temperature of the rats in dose dependent manner. This effect was maximal at dose of 500 mg/kg and it caused significant lowering of body temperature (P< 0.01) up to 4 hour after its administration. The antipyretic effect started as early as 1h and the effect was maintained for 4h, after its administration. Both the standard drug paracetamol 25mg/kg and tested drug H. indicum extract were significantly reduced the yeast elevated rectal temperature, at 2nd, 3rd and 4th hour compared to control group.
Kamboj A, Kumar S, Kumar V. Evaluation of Antidiabetic Activity of Hydroalcoholic Extract of Cestrum nocturnum Leaves in Streptozotocin-Induced Diabetic Rats. Adv. Pharmacol. Sci, 2013; 2013: 4.
Rajan TS, Kumar TR, Kumar EU, Sekar M, Senthil MK. Antidiabetic activity of methanolic extract of hibiscus cannabinus in streptozotocin induced diabetic rats Int. J. Pharma. Bio Sci. 2011; 2(1), 125-130.
Singh G, Singh HB, Mukharjee TK. Ethnomedicine of North East India proceeding of national seminar on traditional knowledge based on herbal medicine and plant resoures of North East India, Utilisation and conservation, National Instistute of Science Communication and Information Resources, CSIR, New Delhi, 2003. p. 364.
Begum TN, Hussain M, Ilyas M, Anand AV. Antipyretic activity of azima tetracantha in experimental animals. Int. J Cur Biomed Phar. Res. 2011; 1(2): 41-44.
Padhan AR, Agrahari AK , Meher A. A Study on antipyretic activity of Capparis zeylanica Linn. plant methanolic extract. Int. J. Pharma. Sci. Res. 2010; 1(3), 169-171.
Kumar PV, Mangilal T, PriyaAS, Jatoth K, Banu RF. Evaluation of antipyretic activity of aqueous extract of curcuma amada. Human Journals. 2015; 3(3), 291-301.
Kokate CK, Practical Pharmacognosy, New Delhi: Vallabh Prakashan; 1994, 14, p.178-182.
Harborne JB, Phytochemical Method, New York: Chapman and Hall; 1984, p.55-82.
How to Cite
Copyright (c) 2020 Mrinmoy Basak, Biplab Kumar Dey
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
In submitting an article to Journal of Applied Pharmaceutical Research (JOAPR) I certify that:
- I am authorized by my co-authors to enter into these arrangements.
- I warrant, on behalf of myself and my co-authors, that:
- the article is original, has not been formally published in any other peer-reviewed journal, is not under consideration by any other journal and does not infringe any existing copyright or any other third party rights;
- I am/we are the sole author(s) of the article and have full authority to enter into this agreement and in granting rights to JOAPR are not in breach of any other obligation;
- the article contains nothing that is unlawful, libellous, or which would, if published, constitute a breach of contract or of confidence or of commitment given to secrecy;
- I/we have taken due care to ensure the integrity of the article. To my/our - and currently accepted scientific - knowledge all statements contained in it purporting to be facts are true and any formula or instruction contained in the article will not, if followed accurately, cause any injury, illness or damage to the user.
- I, and all co-authors, agree that the article, if editorially accepted for publication, shall be licensed under the Creative Commons Attribution-NonCommercial 4.0 International License
- I, and all co-authors, agree that, if the article is editorially accepted for publication in Journal of Applied Pharmaceutical Research (JOAPR) data included in the article shall be made available under the Creative Commons 1.0 Public Domain Dedication waiver, unless otherwise stated. For the avoidance of doubt it is stated that sections 1, 2, and 3 of this license agreement shall apply and prevail.