Subduing the nail barrier with novel herbal penetration enhancers for transungual delivery system
Keywords:
Herbal Formulation, Penetration Enhancers, Transungual Delivery SystemAbstract
Nail fungal infections are very common and also very difficult to treat because of nail morphology, deep penetrability of infectious agent inside nail plate and poor permeability of the nail plate. Transungual delivery shall be the first choice for treatment of nail infection if we get the effective penetration enhancers without causing the serious problem. In this study we tried to scanning some extracts penetration potency through the human cadaver nail plate. Five plants selected for the purpose acacia catechu, rosa hybrid, hibiscus rose-sinensis, tagetes patula, tagetes erecta. For penetration potency first defatted the nail plate with chloroform : methanol (2:1) mixture. Extracts of tagetes erecta, acacia catechu shows 100%, tagetes patula 60% and rosa hybrid 40% from dorsal side of plate. Those extracts were stable by it only. That proves that they may be used as a penetration enhancer to increase the penetration of drug
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References
De Berker D. Fungal nail disease. N Engl J Med. 2009; 360(20):2108-2116.
MacKay-Wiggan J. et al. The diagnosis and treatment of nail disorders: systemic fungual therapy. Dermatol Ther. 2002; 15(2):78-88.
Repka MA, O’Hare J, See CH, Gutta K, Munjal M. Nail morphology studies as assessments for onychomycosis treatment modalities. Int J Pharm, 2002; 245(1-2):25–36.
Jinsong H, Kevin Li S. Transungual Iontophoretic Transport of Polar Neutral and Positively Charged Model Permeants: Effects of Electrophoresis and Electroosmosis. J Pharm Sci, 2008; 97(2):893– 905.
Sudaxshina M, Drug delivery to the nail following topical application, Int J Pharm, 2002; 236 (1-2): 1-26.
K.A. Walters and G.L. Flynn , Permeability characteristics of the human nail plate. Int. J. Cosmet. Sci. 1983; pp. 231–246
Sulzberger A., Allergic eczematous reactions of the nail bed. Persistent subungual and ungual changes based on contact with undercoats containing artificial resins and rubbers. J. Invest. Dermatol. 1948; pp. 67–72.
Walters A., Physicochemical characterisation of the human nail: permeation pattern for water and the homologous alcohols and differences with respect to the stratum corneum. J. Pharm. Pharmacol. 1983; 19: 28–33.
Baran R. and kaoukhov A., “topical antifungal drug for the treatment of onychomycosis: An overview of current strategies for monotherapy and combination therapy” Journal of European Academy of Dermatology and Venereology. 2005; 19: 21-9.
Daswber R.P.R. science of the nail apparatus in “A Text Atlas of Nail Disorders.Techniques in Investigation and in Diagnosis” (3rd Edit), (2003) Taylor & Francis: 1-7.
Murdan S. Drug delivery to the nail following topical application. Int j pharm. 2002; 236 (1-2): 1-26.
Farren, L., Shayler, S. et al., “The fracture properties and mechanical design of human fingernails.” J Exp Biol. 2004; 207: 735-741.
Jarrett, A. and Spearman, R. I. C., “The histochemistry of the human nail.” Arch Derm. 1966; 94: 652-657.
Shuster S “Systemic drug delivery system through application on nail” published under the patent cooperation treaty, international publication number WO 95/23597.
Gupta, A. K. and Ryder, J. E., “The use of oral antifungal agents to treat onychomycosis.” Dermatol Clin. 2003; 21: 469-479.
Doncker D, P., “Pharmacokinetics of orally administered antifungals in onychomycosis.” Int J Dermatol. 1999; 38: 20-27
Palmeri, A., Pichini, S. et al., “Drugs in nails. Physiology, pharmacokinetics and forensic toxicology.” Clin Pharmacokinet. 2000; 38: 95-110.
Mertin, D. and Lippold, B. C., “In-vitro permeability of the human nail and of a keratin membrane from bovine hooves: prediction of the penetration rate of antimycotics through the nail plate and their efficacy.” J. Pharm. Pharmacol.1997; 49: 866-872.
Walters, K. A., Flynn, G. L. et al., “Physicochemical characterization of the human nail: solvent effects on the permeation of homologous alcohols.” J Pharm Pharmacol. 1985; 37: 771-775"rose (plant) - Britannica Online Encyclopedia". Britannica.com. 2007-11-19. Retrieved 2009-12-07
"Rosa Chinensis China Rose PFAF Plant Database". Pfaf.org. Retrieved 2013-03-13.
British Pharmacopoeia, Department of Health, British Pharmacopoeia Commission, London. The Stationary Office,(1999)
Leigh W. H, Ruth H. Watkins, Luis W. Levy, Edmundo Regalado, Diana M. Rivadeneira, Richard B. van Breemen & Steven J. Schwartz, "Carotenoid composition of marigold (Tagetes erecta) flower extract used as nutritional supplement". Journal of Agricultural and Food Chemistry.1999; 47 (10): 4189–4194.
Rosa M Pérez G, Heliodoro H L and Sergio H G, "Antioxidant activity of Tagetes erecta essential oil". Journal of the Chilean Chemical Society. 2006; 51(2): 883–886.
Soule, J. A., "The Biosystematics of Tagetes" Ph.D. Dissertation, University of Texas 1993.
Dutta B. K., Karmakar S., Naglot A., J. C. Aich and M. Begam, "Anticandidial activity of some essential oils of a mega biodiversity hotspot in India". Mycoses. 2007; 50 (2): 121–124.
Mares D, Tosi B, Poli F, Andreotti E, Romagnoli C., "Antifungal activity of Tagetes patula extracts on some phytopathogenic fungi: ultrastructural evidence on Pythium ultimum". Microbiol Res. 2004; 159 (3): 295–304.
Romagnoli1 C., Bruni R., E. Andreotti, M. K. Rai, Vicentini C. B. and D. Mares, "Chemical characterization and antifungal activity of essential oil of capitula from wild Indian Tagetes patula L.".Protoplasma. 2005; 225 (1–2): 57–65.
Mendonca B, Luciana and Dos A L, Beija-flores (Aves, Trochilidae) e seus recursos florais em uma área urbana do Sul do Brasil [Hummingbirds (Aves, Trochilidae) and their flowers in an urban area of southern Brazil]. Revista Brasileira de Zoologia. 2005; 22(1): 51–59.
Gunt B H, Kasting B G, Effect of Hydration on the permeation of Ketoconazole through human nail plate in vitro, Eu Jr Pharm Sc. 2007; 32 :254-260.
Nair A B et al. Alteration of the diffusional barrier property of the nail leads to greater terbinafine drug loading and permeation. Int J Pharm. 2009; 375(1-2):22-27.
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