Precision drug delivery through methotrexate and tofacitinib citrate encapsulated mesoporous silica scaffold

Dinesh Chakole; Amol Rakte; Vishal  Pande; Sachin Kothawade; Jayprakash  Suryawanshi

doi:10.69857/joapr.v12i3.528

Authors

Dinesh Chakole Pacific Academy of Higher Education and Research University, Debari, Udaipur-313003, Rajasthan, India
Amol Rakte Pacific Academy of Higher Education and Research University, Debari, Udaipur-313003, Rajasthan, India
Vishal Pande RSM’s N. N. Sattha College of Pharmacy, Ahmednagar-414001, Maharashtra, India
Sachin Kothawade RSM’s N. N. Sattha College of Pharmacy, Ahmednagar-414001, Maharashtra, India
Jayprakash Suryawanshi RSM’s N. N. Sattha College of Pharmacy, Ahmednagar-414001, Maharashtra, India

DOI:

https://doi.org/10.69857/joapr.v12i3.528

Keywords:

Mesoporous silica nanoparticles, methotrexate, tofacitinib citrate, targeted drug delivery, nanoparticles synthesis, drug encapsulation

Abstract

Background: Advancements in drug delivery aim to enhance outcomes while reducing adverse effects. Mesoporous silica nanoparticles (MSN) offer potential for targeted delivery due to their unique properties, including ordered pore structure, large surface area, and biocompatibility. Methods: MSN were synthesized using tetraethyl orthosilicate (TEOS) and Pluronic F127, then amine-functionalized with 3-aminopropyltriethoxysilane. Methotrexate and tofacitinib citrate were loaded via incipient wetness impregnation. Characterization included FTIR, particle size analysis, TEM, SEM, DSC, XRD, and BET analysis. Results: FTIR confirmed surface modification. Particle size analysis showed nanoscale dimensions. TEM and SEM depicted ordered mesoporous structures. DSC indicated drug crystallinity and MSN amorphism. XRD revealed reduced drug crystallinity in MSN. BET analysis demonstrated high MSN surface area and pore volume. Drug-loading efficiency was 62.44%. Conclusion: Comprehensive synthesis and characterization of MSN for targeted drug delivery were achieved successfully, highlighting their potential in overcoming conventional therapy limitations.

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References

Tang N, Liu X, Jia MR, Shi XY, Fu JW, Guan DX, Ma LQ. Amine- and thiol-bifunctionalized mesoporous silica material for immobilization of Pb and Cd: Characterization, efficiency, and mechanism. Chemosphere, 291, 132771 (2022)

Corell Escuin P, García-Bennett A, Ros-Lis JV, Argüelles Foix A, Andrés A. Application of mesoporous silica materials for the immobilization of polyphenol oxidase. Food Chem, 217, 360-3 (2017)

Dudarko OA, Barany S. Synthesis and characterization of sulfur-containing hybrid materials based on sodium silicate. RSC Adv, 8, 37441-50 (2018)

Pal N, Lee JH, Cho EB. Recent Trends in Morphology-Controlled Synthesis and Application of Mesoporous Silica Nanoparticles. Nanomaterials (Basel), 10 (11), 2122 (2020)

Lérida-Viso A, Estepa-Fernández A, García-Fernández A, Martí-Centelles V, Martínez-Máñez R. Biosafety of mesoporous silica nanoparticles; towards clinical translation. Adv Drug Deliv Rev, 201, 115049 (2023)

Chircov C, Spoială A, Păun C, Crăciun L, Ficai D, Ficai A, Andronescu E, Turculeƫ ȘC. Mesoporous Silica Platforms with Potential Applications in Release and Adsorption of Active Agents. Molecules, 25 (17), 3814 (2020)

Tran V, Shammas RM, Sauk JS, Padua D. Evaluating tofacitinib citrate in the treatment of moderate-to-severe active ulcerative colitis: design, development, and positioning of therapy. Clin Exp Gastroenterol, 12, 179-191 (2019)

Ozdede A, Yazıcı H. Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis. N Engl J Med, 386 (4), 1766 (2022)

Xu C, Lei C, Yu C. Mesoporous Silica Nanoparticles for Protein Protection and Delivery. Front Chem, 7, 290 (2019)

Peng B, Zhou JF, Chen H, Ding M, Zhu YS, Albela B, Wu P, Bonneviot L, Zhang K. Tetraalkoxysilane-Assisted Self-Emulsification Templating for Controlled Mesostructured Silica Nanoparticles. Langmuir, 39 (10), 3610-8 (2023)

Wang Z, Wu S, Wang J, Yu A, Wei G. Carbon Nanofiber-Based Functional Nanomaterials for Sensor Applications. Nanomaterials (Basel), 9 (7), 1045 (2019)

Li X, Han J, Qin J, Sun M, Wu J, Lei L, Li J, Fang L, Yang YW. Mesoporous silica nanobeans dual-functionalized with AIEgens and leaning pillar[6]arene-based supramolecular switches for imaging and stimuli-responsive drug release. Chem Commun (Camb), 55, 14099-14102 (2019)

Bhavsar DB, Patel V, Sawant KK. Design and characterization of dual responsive mesoporous silica nanoparticles for breast cancer targeted therapy. Eur J Pharm Sci, 152, 105428 (2020)

Xu B, Li S, Shi R, Liu H. Multifunctional mesoporous silica nanoparticles for biomedical applications. Signal Transduct Target Ther, 8, 435 (2023)

Dehnavian M, Dehghani A, Moradi L. Introducing a green nanocatalytic process toward the synthesis of benzo[a]pyrano-[2,3-c] phenazines utilizing copper oxide quantum dot-modified core-shell magnetic mesoporous silica nanoparticles as high throughput and reusable nanocatalysts. RSC Adv, 12, 25194-25203 (2022)