Clock gene variation in type 2 diabetes: a review


  • Nushrat Parveen Columbia Institute of Pharmacy, Vill. Tekari, Near Vidhan Sabha, Raipur (CG) 493111
  • Trilochan Satapathy Columbia Institute of Pharmacy, Vill. Tekari, Near Vidhan Sabha, Raipur (CG) 493111
  • Pushpa Prasad Columbia Institute of Pharmacy, Vill. Tekari, Near Vidhan Sabha, Raipur (CG) 493111
  • Amit Roy Columbia Institute of Pharmacy, Vill. Tekari, Near Vidhan Sabha, Raipur (CG) 493111


Clock genes, Diabetes mellitus, Pathophysiology, Single nucleotide polymorphisms, Obesity


Diabetes mellitus type 2 is a long-standing metabolic disorder that is exemplify by high blood sugar, insulin resistance, and comparative lack of insulin. General symptoms include increased thirst, frequent urination, and unsolved weight loss. Type 2 diabetes is mainly due to obesity and not sufficient work out in public who are heritably prone. Circadian clocks are significant to keep the moment in the sequence of physiological practice, series of behaviour and metabolism. The plasma level of glucose and numerous hormones implicated in glucose homeostasis for example insulin and glucagon exhibit circadian variation. Circadian desynchrony, a feature of alter occupation elevated-fat diet feed and sleep distraction in individual have been linked with metabolic disorders for instance obesity and type 2 diabetes. Circadian rhythm distraction can cause different fitness disarray. Current reading has discovered a seal connection among the pathophysiology of metabolic condition, which is characterized by obesity and hyperglycemia, and the operation of interior molecular clocks


Download data is not yet available.


Stamenkovic et al.,”Clock genes in human islets”, Metabolism: Clinical and Experimental, 2012,vol. 61:7,pp. 978-985

Marcheva B, Ramsey KM, Affinati A, Bass J (2009) Clock genes and metabolic disease. J Appl Physiol 107: 1638-1646

Corella et al. Cardiovascular Diabetol (2016) 15:4, DOI 10.1186/s12933-015-0327

Leon BM, Maddox TM. Diabetes and cardiovascular disease: epidemiology, biological mechanisms, treatment recommendations and future research. World J Diabetes. 2015;6:1246–58.

Pandey A, Chawla S, Guchhait P. Type 2 diabetes: current understanding and future perspectives. IUBMB Life. 2015;67:506–13. Sgunasekar Date:22/3/08 Time:12:33:54 Stage:First Proof File Path://spiina1001z/womat/production/PRODENV/0000000005/0000006643/0000000016/0000773876. D Proof by: QC by: Clock Genes Au1, URS ALBRECHT, JURGEN A. RIPPERGER Department of Medicine, Division of Biochemistry, University of Fribourg, Fribourg, Switzerland

Young MW, Kay S (2001) Time zones: a comparative genetics of circadian clocks. Nat Rev Genet 2:702–715

Ko CH, Takahashi JS (2006) Molecular components of the mammalian circadian clock. Hum Mol Genet 15(2):R271–R277

Rhythmic Diurnal Gene Expression in Human Adipose Tissue From Individuals Who Are Lean, Overweight, and Type 2 Diabetic Daniella T. Otway, Simone Mäntele, Silvia Bretschneider, John Wright, Paul Trayhurn, Debra J. Skene, M. Denise Robertson, and Jonathan D. Johnston

Oishi K, Atsumi G, Sugiyama S, et al. Disrupted fat absorption attenuates obesity induced by a high-fat diet in Clock mutant mice. FEBS Lett 2006;580:127–130

David Gatfield and Ueli Schibler*, Department of Molecular Biology and National Center for Competence in Research Frontiers in Genetics, Sciences III, University of Geneva, 30, Quai Ernest Ansermet, CH-1211 Geneva-4, Switzerland

Circadian control of glucose metabolism, Andries Kalsbeek, Susanne la Fleur Eric FliersÓ 2014 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY NC-ND license

Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F.,Schibler, U., 2000. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus.Genes & Development 14:2950-2961

Kennaway, D.J., Owens, J.A., Voultsios, A., Boden, M.J., Varcoe, T.J., 2007.Metabolic homeostasis in mice with disrupted Clock gene expression in peripheral tissues. American Journal of Physiology 293:R1528-R1537

Clock Genes and Energy Metabolism H.-K. Hong et al. P.J. Shiromani et al. (eds.), Sleep Loss and Obesity: Intersecting Epidemics DOI 10.1007/978-1-4614-3492-4_2, © Springer Science+Business Media, LLC 2012

Otway DT, Frost G, Johnston JD: Circadian rhythmicity in murine pre-adipocyte and adipocyte cells. Chronobiol Int 26:1340-1354, 2009

Lyssenko V, Nagorny CL, Erdos MR,et al. (2009) Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet 41: 82-88

Ko CH, Takahashi JS (2006) Molecular components of the mammalian circadian clock. Hum Mol Genet 15(2): R271–R277



How to Cite

Parveen, N. ., Satapathy, T., Prasad, P., & Roy, A. (2015). Clock gene variation in type 2 diabetes: a review. Journal of Applied Pharmaceutical Research, 3(1), 01-03. Retrieved from