Enhancement of curcumin's physicochemical properties by developing its eutectic mixtures
DOI:
https://doi.org/10.18231/j.joapr.2024.12.1.71.81Keywords:
curcumin, DSC, XRD, stability, DissolutionAbstract
Background: Curcumin is a compound obtained from the rhizomes of Curcuma Longa. It has various pharmacological properties like anti-inflammatory, anti-oxidant, anti-hyperlipidemic, etc. However, it also has some limitations that restrict its use as a medicine. Material and method: In the present study, a eutectic mixture of curcumin and glycine (35% and 65%) was prepared to improve its dissolution rate and photostability, characterized by DSC, FTIR, and XRD studies. Result and discussion: After 40 minutes, the eutectic mixture dissolved 10-fold more than the parent drug. The photostability studies were conducted according to ICH Q1B guidelines; after the seventh day of accelerated photostability studies, curcumin-glycine eutectic mixtures showed 36% degradation, 34% less than pure curcumin. Conclusion: The present study revealed that the physicochemical properties of BCS class II drugs can be improved by forming an eutectic mixture.
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Copyright (c) 2024 Sunita Ahlawat, Vikas Budhwar, Manjusha Choudhary
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