Enhancement of curcumin's physicochemical properties by developing its eutectic mixtures


  • Sunita Ahlawat Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak -124001, Haryana
  • Vikas Budhwar Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak -124001, Haryana
  • Manjusha Choudhary Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136118




curcumin, DSC, XRD, stability, Dissolution


Background: Curcumin is a compound obtained from the rhizomes of Curcuma Longa. It has various pharmacological properties like anti-inflammatory, anti-oxidant, anti-hyperlipidemic, etc. However, it also has some limitations that restrict its use as a medicine. Material and method: In the present study, a eutectic mixture of curcumin and glycine (35% and 65%) was prepared to improve its dissolution rate and photostability, characterized by DSC, FTIR, and XRD studies. Result and discussion: After 40 minutes, the eutectic mixture dissolved 10-fold more than the parent drug. The photostability studies were conducted according to ICH Q1B guidelines; after the seventh day of accelerated photostability studies, curcumin-glycine eutectic mixtures showed 36% degradation, 34% less than pure curcumin. Conclusion: The present study revealed that the physicochemical properties of BCS class II drugs can be improved by forming an eutectic mixture.


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How to Cite

Ahlawat, S., Budhwar, V. ., & Choudhary, M. . (2024). Enhancement of curcumin’s physicochemical properties by developing its eutectic mixtures . Journal of Applied Pharmaceutical Research, 12(1), 71-81. https://doi.org/10.18231/j.joapr.2024.