Comparative study of magnesium sulphate nebulization and lignocaine nebulization in prevention of postoperative sore throat (POST)

Gopal  Sharma; Kumar  Asnani; Sanjay  Kalani; Mohit  Kumar

doi:10.18231/j.joapr.2023.11.1.1.8

Authors

Gopal Sharma Department of Anaesthesiology, Govt. Satellite Hospital, Bani Park Jaipur, 302033
Kumar Asnani Department of Anaesthesiology, RUHS-CMS, Jaipur, 302033
Sanjay Kalani Department of Anaesthesiology, Government Medical College, Kota
Mohit Kumar Department of Anaesthesiology, RUHS-CMS, Jaipur 302033

DOI:

https://doi.org/10.18231/j.joapr.2023.11.1.1.8

Keywords:

Post operative sore throat (POST), general anaesthesia (GA), magnesium sulfate (MgSO4)

Abstract

Background: General anaesthesia (GA) includes intubation a necessary step to provide adequate ventilation in patients under anaesthesia along with protection of airway from regurgitation and aspiration. Postoperative sore throat (POST), hoarseness of voice, cough are common sequelae. The present study compares the efficiency of preoperative nebulization of lignocaine hydrochloride and magnesium sulphate for reducing the incidence of POST in patients under GA. Methods: The study conducted in GMC Kota and attached hospitals on 100 patients of surgery duration one hour to three hours. Patients were randomly allocated in two groups Lignocaine group and Magnesium group. Results: The majority of patients belonged to the age between 40 and 70 years. There was no significant difference in the mean pulse rate, SBP, mean SpO₂. Comparison of sore throat in both the groups at rest, just after extubation, 2 hours, 8 hours, 24 hours and 48 hours showed incidence more common in lignocaine group than magnesium group but no significant difference (P>0.05). Hoarsness after extubation reduced within 24 hours in Magnesium group in comparison to Lignocaine group where it persists till 48 hrs. Conclusion: Incidence of sore throat, hoarseness of voice and cough was more common in lignocaine group and more in female patients. Both drugs can be used for prevention of postoperative sore throat, but magnesium sulphate has better results.

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References

Carlos A,Puyo, Sally M, Tricomi, Thomas E, Dahms. Early Biochemical Markers of Inflammation in a Swine Model of Endotracheal Intubation. Critical Care Medicine 109, 88-94 (2008).

Doukumo DM, Faponle AF, Bolaji BO, Adenekan AT, Olateju SOA. Effects of lidocaine and K-Y jellies on sore throat, cough, and hoarseness following endotracheal anesthesia. Journal of the west African college of surgeons 1, 3 (2011).

Edomwonyi NP,Ekere IT, OMO E, Rupasinghe A. Postoperative throat complications after tracheal intubation. Ann Afr Med 5, 28-32 (2006).

Kolawale IK, Ishaq MS. Post anaesthetic respiratory complaints following endotracheal anaesthesia in lower abdominal obstetrics and gynaecology surgery. Nig j clinic pract 11, 225-30 (2008)

Mchardy FE, Chung F. Post op sore throat cause, prevention and treatment. Anaesthesia 54 (5), 444-53 (1999).

Christensen AM, Willemoes, Larsen H, Lundby L, Jakobsen KB. Postoperative throat complaints after tracheal intubation. British Journal of Anaesthesia 73, 786–7(1994).

Herlevsen P, Bredahl C, Hindsholm K, Kruhoffer PK. Prophylactic laryngo-tracheal aerosolized lidocaine against postoperative sore throat. Acta Anaesthesiologica Scandinavica. 36, 505–7(1992).

Stout DM, Bishop MJ, Dwersteg JF, Cullen BF. Correlation of endotracheal tube size with sore throat and hoarseness following general anaesthesia. Anaesthesiology 67, 419–21 (1987).

Nordin U, Lindholm CE, Wolgast M. Blood flow in the rabbit tracheal mucosa under normal conditions and under the influence of tracheal intubation. Acta Anaesthesiologica Scandinavica 21, 81–94 (1997).

Loeser EA, Stanley TH, Jordan W, Machin R.Postoperative sore throat: influence of tracheal tube lubrication versus cuff design. Canadian Anaesthetists Society Journal. 27, 156–8 (1980).

Capan LM, Bruce DL, Patel KP, Turndor FH. Succinylcholine induced postoperative sore throat. Anesthesiology 59, 202–6 (1983).

Higgins PP, Chung F, Mezei G. Postoperative sore throat after ambulatory surgery. British Journal of Anaesthesia. 88 (4), 582-84(2002)

Yadav M, Chalumuru N Gopinath R. Effect of magnesium sulfate nebulization on the incidence of postoperative sore throat. Journal of Anaesthesiology Clinical Pharmacology 32, 2 (2016).

Houman T, Seyed AmirM, Alireza F. Magnesium and Ketamine Gargle and Postoperative Sore Throat. Anesth and Pain Med. 5, 3 (2015).

Jafari H, Ariaeifar MR, Charati YJ, Soleimani A, Formi EN. The effect of green tea gargle solution on sore throat after coronary artery bypass grafting: A randomized clinical trial. Anesth and Pain Med. 6, 3 (2016).

Gaur P, Ubale P, Khadanga P. Efficacy and safety of using air versus alkalinized 2% lignocaine for inflating endotracheal tube cuff and its pressure effects on incidence of postoperative coughing and sore throat. Anesth Essays Res. 11(4), 1057-63 (2017).

Najafi A, Imani F, Makarem J, Khajavi MR, Etezadi F, Habibi S, Shariat Moharari R. Postoperative sore throat after laryngoscopy with macintosh or glide scope video laryngoscope blade in normal airway patients. Anesth Pain Med 4, e15136. (2014).

David MK, Loraine SS, Paul NA. Noval preoperative pharmacologic method of preventing postoperative sore throat due to tracheal intubation. AANA Journal. 82(3), 188 (2014).

Hung, Nan K, Ching T, Chan, Shun M, Chueng H et al. Effect of postoperative sore throat of spraying the endotracheal tube cuff with benzydamine hydrochloride, 10% lidocaine and 2% lidocaine. Anesthesia and Analgesia. 111(4), 882-86(2010).

Turnbull RS. Benzydamine hydrochloride (Tantum) in the management of oral inflammatory conditions. Journal of the Canadian Dental Association. 61, 127–34 (1995).

Shirk MB, Donahue KR, Shirvani J. Unlabeled uses of nebulized medications. Am J Health Syst Pharm 63, 1704-16 (2006).

Gupta SK, Tharwani S, Singh DK, Yadav G. Nebulized magnesium for prevention of postoperative sore throat. Br J Anaesth 108, 168-9. (2012).