Review on medicated chocolate takes a patient-centered approach to drug delivery

Moumita Paul Paul; Priyanka Ranabhat Ranabhat; Deepika Khatiwara Khatiwara; Arnab Bagchi

doi:10.18231/j.joapr.2021.16.22

Authors

Moumita Paul Department of Pharmaceutics, Himalayan Pharmacy Institute, Majhitar, East Sikkim 737136
Priyanka Ranabhat Department of Pharmaceutics, Himalayan Pharmacy Institute, Majhitar, East Sikkim 737136
Deepika Khatiwara Department of Pharmaceutics, Himalayan Pharmacy Institute, Majhitar, East Sikkim 737136
Arnab Bagchi Department of Pharmaceutics, Himalayan Pharmacy Institute, Majhitar, East Sikkim India 737136

DOI:

https://doi.org/10.18231/j.joapr.2021.16.22

Keywords:

Medicated Chocolate, age-appropriate, paediatric drug delivery

Abstract

The goal is to create medicinally beneficial chocolate that has no negative side effects. Carob (Ceratonia siliqua), a basic ingredient in many chocolate formulations, was substituted for cocoa since it requires a large amount of sugar in the formulation and includes caffeine, which stimulates the CNS. Carob is high in natural sweeteners, has no fat, caffeine, or oxalates, and is high in antioxidants, which assist to prevent a variety of ailments. Many traditional drug delivery systems are ineffective for paediatric patients because their developmental state and dosing requirements differ from those of other groups of people. Age-appropriate medicines require technological platforms to ensure patient acceptability while maintaining safety, efficacy, accessibility, and affordability. Recent methods and accomplishments in the field of age-appropriate drug delivery for paediatric patients are discussed, including patient-centric formulations, administration devices, and packaging solutions.

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References

Devare RR, Chaudhari AS, Dewang SP, Patil B.V, Patil MA, Pawar PS. Chocolate Formulation as Drug Delivery System for Paediatrics. Indian Journal of Drugs, 7(4), 133-139 (2019)

Kolekar SY, Mulani AS, Tamboli AF, More NH and Misal AA. Formulation and Evaluation of Paediatric Herbal Chocolate. European Journal of Biomedical and Pharmaceutical sciences, 8(6), 458-462(2021)

Meng CC, Jalil AM, Ismail A. Phenolic and theobromine contents of commercial dark, milk and white chocolates on the Malaysian market. Molecules, 14, 200–209, (2009)

Lopez FL, Ernest TB, Tuleu C, Gul MO. Formulation approaches to paediatric oral drug delivery: benefits and limitations of current platforms. Archives of Applied Science Research, 12(11), 1727-40(2015)

Viswanath V, Narasimha R B, Purushothaman M, Sireesha S. Formulation and evaluation of fexofenadine hydrochloride and paracetamol chocolate for paediatrics. World Journal of Pharmaceutical Research, 4(9), 842-858, (2015)

Pawar PG, Darekar AB, Saudagar RB. Medicated chocolate and lollipop: a novel drug delivery system for pediatric patient. International Journal of Pharmaceutical Sciences, 9(1): 677-6969(2018)

Reddy S, Mounika K, Venkatesham A. Design and fabrication of medicated chocolate formulation by chocolate DDS. International Journal of Current Pharmaceutical Research, 9(5), 128-133(2017)

Haritha K, Kalyani L, Lakshmana RA. Health Benefits of Dark Chocolate. Journal of Advanced Drug Delivery, 1(4), 184-195, (2014)

Martín MA, Goya L, Ramos S. Antidiabetic actions of cocoa flavanols. Mol. Nutr. Food Res., 60, 1756–1769 (2016)

Matsumoto C, Petrone AB, Sesso HD, Gaziano JM, Djousse L. Chocolate consumption and risk of diabetes mellitus in the Physicians’ Health Study. Am. J. Clin. Nutr, 101, 362–367(2015)

Maskarinec G, Jacobs S, Shvetsov Y, Boushey CJ, Setiawan VW, Kolonel LN, Haiman CA, Le Marchand L. Intake of cocoa products and risk of type-2 diabetes: The multiethnic cohort. Eur. J. Clin. Nutr, 73, 671–678 (2019)

Yuan S. Li X, Jin Y, Lu J. Chocolate Consumption and Risk of Coronary Heart Disease, Stroke, and Diabetes: A Meta-Analysis of Prospective Studies. Nutrients, 9, 688 (2017)

Dong JY, KimuraT, Ikehara S, Cui M, Kawanishi Y, Yamagishi K, Ueda K, Iso H. Chocolate consumption and risk of gestational diabetes mellitus: The Japan Environment and Children’s Study. Br. J. Nutr., 122, 936–941(2019)

Gu Y, Yu S, Lambert JD. Dietary cocoa ameliorates obesity-related inflammation in high fat-fed mice. Eur. J. Nutr, 53, 149–158(2014)

Massolt ET, Van HPM, Rehfeld JF, Posthuma EF, Van DVE, Schweitzer DH. Appetite suppression through smelling of dark chocolate correlates with changes in ghrelin in young women. Advanced biomedical research, 161, 81–86(2010)

Magrone T, Russo MA, Jirillo E. Cocoa and dark chocolate polyphenols: From biologym to clinical applications. Front. Immunol ,8, 677(2017)

Greenberg JA, Buijsse B. Habitual chocolate consumption may increase body weight in a dose-response manner. Farmaci. Sci Ed, 8, 70271(2013)

Kord VH, Ghaedi E, Nazary VA, Mohammadi H, Shab-Bidar S. Does cocoa/dark chocolate supplementation have favorable effect on body weight, body mass index and waist circumference? A systematic review, meta-analysis and dose-response of randomized clinical trials. Crit. Rev. Food Sci. Nutr, 59, 2349–2362(2019)

Diella G, Di C, Lorusso A, Summo MP, Caggiano G, Caponio F, Montagna MT, Portincasa P. Distinct Effects of two Almond Cultivars on Agreeability and Gastrointestinal Motility in Healthy Subjects: More than mere Nutraceuticals. J. Gastrointest. Liver Dis. Advanced biomedical research, 27, 31–39(2018)

Lee Y, Berryman CE, West SG, Chen CO, Blumberg JB, Lapsley KG, Preston AG, Fleming JA, Kris EPM. Effects of dark chocolate and almonds on cardiovascular risk factors in overweight and obese individuals: A randomized controlled-feeding trial. J. Am. Heart Assoc., 6, 5162 (2017)

Tokede OA, GazianoJM, Djousse L. Effects of cocoa products/dark chocolate on serum lipids: A meta-analysis. Eur. J. Clin. Nutr., 65, 879–886 (2011)

Allen RR, Carson L, Kwik UC, Evans EM, Erdman JW. Daily consumption of a dark chocolate containing flavanols and added sterol esters affects cardiovascular risk factors in a normotensive population with elevated cholesterol. J. Nutr., 138, 725–731(2008)

Di Renzo L, Rizzo M, Sarlo F, Colica C, Iacopino L, Domino E, Sergi D, De LA. Effects of dark chocolate in a population of normal weight obese women: A pilot study. Eur. Rev. Med. Pharm, 17, 2257–2266(2013)

Massot CM, Pérez BT, Franch A, Castell M, Pérez-CFJ. Cocoa modulatory effect on rat faecal microbiota and colonic crosstalk. Arch. Biochem. Biophys.,527, 105–112(2012)

Tzounis X, Rodriguez MA, Vulevic GR, Kwik UC, Spencer JP. Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study. Am. J. Clin. Nutr., 93, 62–72 (2011)

Tzounis X, Vulevic J, Kuhnle GG, George T, Leonczak J, Gison GR, Kwik U C, Spencer JP. Flavanol monomer-induced changes to the human faecal microflora. Br. J. Nutr., 99, 782–792 (2008)

Jang S, Sun J, Chen P, Lakshman S, Molokin A, Harnly JM, Vinyard BT, Urban JF, Davis CD, Solano AG. Flavanol-enriched cocoa powder alters the intestinal microbiota, tissue and fluid metabolite profiles, and intestinal gene expression in pigs. J. Nutr., 146, 673–680(2016)

Ramiro PE, Perez CFJ, Ramos RS, Perez BT, Castellote C, Permanyer J, Franch A, Izquierdo PM, Castell M. Intestinal immune system of young rats influenced by cocoa-enriched diet. J. Nutr. Biochem., 19, 555–565(2008)

Esser D, Mars M, Oosterink E, Stalmach A, Müller M, Afman LA. Dark chocolate consumption improves leukocyte adhesion factors and vascular function in overweight men. In.J.Pharm.Sci, 28, 1464–14(2014)

Sumiyoshi E, Matsuzaki K, Sugimoto N, Tanabe Y, Hara T, Katakura H, Miyamoto M, Mishima S, Shido O. Sub-Chronic Consumption of Dark Chocolate Enhances Cognitive Function and Releases Nerve Growth Factors: A Parallel-Group Randomized Trial. Nutrients, 11, 2800 (2019)

Wasik A, Antkiewicz ML. The mechanism of neuroprotective action of natural compounds. Pharmacol. Rep., 69, 851–860(2017)

Madhavadas S, Kapgal VK, Kutty BM, Subramanian S. The neuroprotective effect of dark chocolate in monosodium glutamate-induced nontransgenic Alzheimer disease model rats: Biochemical, behavioral, and histological studies. J. Diet. Suppl., 13, 449–460(2016)

Wrigley S, Arafa D, Tropea D. Insulin-like growth factor 1: At the crossroads of brain development and aging. Front. Cell. Neurosci., 11, 14(2017)

Alonso C, Guilarte M, Vicario M, Ramos L, Ramadan Z, Antolin M, Martinez C, Rezzi S, Saperas E, Kochhar S. Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation. Gastroenterology, 135, 163–172(2008)

Martin FP, Antille N, Rezzi S, Kochhar S. Everyday eating experiences of chocolate and non-chocolate snacks impact postprandial anxiety, energy and emotional states. Nutrients, 4, 554–567 (2012)

Alonso C, Guilarte M,Vicario M, Ramos L, Ramadan Z, Antolin M, Martinez C, Rezzi S, Saperas E, Kochhar S. Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation. Gastroenterology, 135, 163–172 (2008)

Martin FP, Antille N, Rezzi S, Kochhar S. Everyday eating experiences of chocolate and non-chocolate snacks impact postprandial anxiety, energy and emotional states. Nutrients, 4, 554–567(2012)

Silva NR. Chocolate consumption and effects on serotonin synthesis. Arch. Intern. Med., 170, 1608–1609 (2010)

Salonia A, Fabbri F, Zanni G, Scavini M, Fantini GV, Briganti A, Naspro R, Parazzini F, Gori E, Rigatti P. Chocolate and women’s sexual health: An intriguing correlation. J. Sex Med., 3, 476–482(2006)

Martinez GD, Bonilla JH, Morales OA, Henriksen SJ, Velazquez MJ, Prospero GO. Oleamide and anandamide effects on food intake and sexual behavior of rats. Neuro.sci. Lett., 364, 1–6, 2004.

Loullis A, Pinakoulaki E. Carob as cocoa substitute: a review on composition, health benefits and food applications. Eur Food Res. Technol., 244:959–977 (2018)

Nugent AP. Health properties of resistant starch. Nutrition Bulletin, 30, 27-54 (2005)

Champ MMJ. Physiological aspects of resistant starch and in vivo measurements. Int. J. Res. Pharma. Biomedical Sci., 87(3), 749-755(2004)