Formulation and evaluation of in situ ophthalmic gel of loteprednol etabonate
DOI:
https://doi.org/10.18231/j.joapr.2021.25.29Keywords:
Occular, In situ gel, pH triggered, Loteprednol etabonateAbstract
The aim of present study was to prepared ocular in-situ gel to increase the residence time of drug in cornea for improvement of ocular bioavailability of drug. In situ gel of Loteprednol etabonate was prepared by using carobopol 940 and different grades of HPMC in different ratios by pH triggered method. The prepared in situ gels were evaluated for pH, drug content, viscosity, gelling time, gelling strength spreadability and sterility testing. In vitro drug release study was carried by using diffusion cell with dialysis membrane. The drug content and pH of the formulation were found to be satisfactory. The gelling strength was found to be in the range of 34 seconds to 91 seconds. The viscosity and spredability of the formulations were found to be satisfactory. Formulation F5 containing 0.3 % carobopol 940 and 0.6 % HPMC K4M showed highest drug release of 80.30 %. The developed formulations showed sustained release of drug up to 8 hrs. From in-vitro drug release studies, it could be concluded that the developed in-situ gelling systems were thus a better alternative to conventional eye drops.
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References
Nalla A, Chinnala KM. In-situ ophthalmic drug delivery systems- an overview. Indo American Journal of Pharmaceutical Sciences, 3(3), 202-208 (2016).
Sirisuru P., Parvathi M., Formulation and evaluation of in-situ gelling system for ocular delivery of timolol maleate. International Journal of Pharmaceutical, Chemical and Biological Sciences, 3(1), 81-89 (2014).
Mittal N, Kaur G. In situ gelling ophthalmic drug delivery system: formulation and evaluation. Journal of Applied Polymer Science, 1-9 (2013).
Arora K, Singh S. Preparation and evaluation of pH and temperature sensitive polymer based in-situ gel for ocular delivery. World Journal of Pharmacy and Pharmaceutical Sciences, 6 (1), 1366-1381 (2017)
Gupta C, Juyal V, Nagaich U. Formulation, optimization, and evaluation of in-situ gel of moxifloxacin hydrochloride for ophthalmic drug delivery. International Journal of Applied Pharmaceutics, 11(4), 147-158 (2019)
Rajoria G and Gupta A. In-situ gelling system: a novel approach for ocular drug delivery. American Journal of PharmTech Research, 2, 2249-3387 (2012)
Rathore KS. In-situ gelling ophthalmic drug delivery system: an overview. Int J Pharm Sci Res, 2, 30-34 (2010)
Amaliyar PR and Chaudhary S. In-situ gel forming a novel approach for sustained ophthalmic drug delivery. International Journal of Pharmaceutical, Chemical and Biological Sciences, 3(2), 502-524 (2014)
Cao Y et al. Poly (Nisopropylacrylamide)-chitosan as thermosensitive in- situ gel-forming system for ocular drug delivery. Journal of Controlled Release, 186-194 (2007).
Patil AP, Tagalpallewar AA and Rasve GM. A novel ophthalmic drug delivery systems: in- situ gel. International Journal of Pharmaceutical Sciences and Research, 3, 2938-2946 (2012)
Pallavi R, Kute SB, Gondkar and Saudagar RB, Ophthalmic in-situ gel: an overview. World Journal of Pharmaceutical Research, 4(4), 549-568 (2015)
Kavitha K and Rajas NJ, Sustained ophthalmic delivery of levofloxacin hemihydrate from an ion activated in situ gelling system. International Journal of PharmTech Research, 3(2), 702-706 (2011)
Garge L and Saudagar R. Ophthalmic pH sensitive in-situ gel: a review. Journal of drug delivery and therapeutics 9(2), 682-689 (2019)
Rukari TG, Jadhav AS, Londhe RA and Phalke PL. A review on ophthalmic in situ gels. American Journal of Pharmtech Research, 9(2), 159-170 (2019)
Chavan PM and Vyas S. A novel approach in-situ gel for sustained drug delivery: a review. International Jounral of Pharmceutics, 9(4), 260-280 (2017)
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Copyright (c) 2021 Shoaeba Shaikh , Sharav Desai, Hitesh Jain, Asit Sahu, D. B. Meshram
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