A short glimpse on promising pharmacological effects of Begenia ciliata
Keywords:
antitussive, antioxidant, antibacterial, antifungal, hypoglycemic, toxicological, antineoplasticAbstract
Bergenia ciliata is a potent indigenous folk medicine that has been proved fruitful in the treatment of various adverse conditions of the body. The major chemical constituents of plant include tannic acid, gallic acid, glucose, metarbin, albumen, bergenin, (+)-catechin, gallicin. Bergenia ciliata was subjected to bioactivity analysis. The plant has antitussive, antiulcer, antioxidant, antibacterial, hypoglycemic, toxicological activity. It was observed that root and leaves extract were promising as antifungal agent. The root and leaves extract were effective against Microsporum canis, Pleuroetus oustreatus and Candida albicans. All the extracts except chloroform extract of root and leaves of Bergenia ciliata were found to possess hypoglycemic activity in Streptozotocin (STZ) treated rats. The methanolic extract exhibited significant anti-tussive activity in a dose-dependent manner. B. ciliata bear potent anti-neoplastic activities that may have prospective clinical use as precursor for preventive medicine. Methanolic and aqueous B. ciliata rhizome extracts were found to possess antioxidant activity, including reducing power, free radical scavenging activity and lipid peroxidation inhibition potential. Bergenia ciliata extracts exhibit a narrow spectrum antibacterial activity. The results obtained thus suggest that extracts of B. ciliata have promising therapeutic potential and could be considered as potential source for drug development by pharmaceutical industries.
Downloads
References
Nazir N, Koul S, Qurishi M A, Najar M H, Zargar MI, Evaluation of antioxidant activity and antimicrobial activites of bergenin and its derivatives obtain by chemoenzymatic synthesis. Eur J Med Chem, 46, 2011, 2415-2420.
Rates SMK, Plant as source of drug, Toxicon, 39, 2001, 603-613
World Health Organization. Traditional Medicine Strategy. Geneva: World Health Organisatin; 2002-2005.
Anon. Herbal Medicine Overview. From: http://medicinalplants.webgosearch.com/HERBAL-MEDICINE-OVERVIEW.php.Retrieved on 15th May 2006
DiPasquale R. The aboca museum: Displaying the history of herbal medicine in Italy and Europe. The Journal of American botanical Council 2005; 65:50-57.
Majupuri TC. Religious plants. In: Majupuria TC, Majupuria RK eds. Nepal Nature’s Paradise. India: M. Devi Publishers; 1999. p. 298-304.
Donald PB. Medicinal plants and phytomedicines. Linking plant biochemistry and physiology to human health. Plant Physiology 2000; 124: 507-514.
S. Sinha, T. Murugesan, K. Maiti, J.R. Gayen, B. Pal, M. Pal and B.P. Saha (2001). Antibacterial activity of Bergenia ciliata rhizome. Fitoterapia 72(5), 550-552.
S. Sinha, T. Murugesan, M. Pal and B.P Saha (2001). Evaluation of anti-tussive activity of Bergenia ciliata Sternb. rhizome extract in mice. Phytomedicine 8(4), 298-301.
M. Islam, I. Azhar, U. Khan, M. Aslam, A. Ahmad and Shahbuddin (2002). Bioactivity evaluation of Bergenia ciliata. Pak J Pharm Sci. 15(1), 15-33.
Mazhar-ul-Islam, Iqbal Azhar, Khan Usmanghani, ohammad Aslam Gill, Shahab-Ud-Din and Afzal Ahmad. Antifungal activity evaluation of Bergenia ciliata:Pakistan Journal of Pharmacology Vol.19, No.2, July 2002, pp.1-6.
Gulfraz M, Cytoprotective effects of Bergenia ciliata Sternb, extract on gastric ulcer in rats, Phytother Res, 21(12), 2007, 1217-20.
Stuffness M, Pezzuto JM, Assay related to cancer drug discovery. In Hostettmann K.(ed). Methods in plant biochemistry. Assays for Bioactivity, 6. Academic press-London, 1990, 71-133.
Islam M, Azhar I, Azhar F, Usmanghani K, Gill MA, Ahmad A, Shahabuddin. Evalution of antibacterial activity of Bergenia ciliate, A Pakistan J Pharmaceutical Sci, 15(2), 2002, 21-27.
Rajbhandari M, Mentel R, Jha PK, Chaudhary RP, Bhattarai S, Gewali MB, Karmacharya N, Hipper M, Lindequist U, Antiviral Activity of Some Plants Used in Nepalese Traditional Medicine, eCAM, 6(4), 2007, 517–522.
Umashankar DC, Phytochemical and anti-inflammatory investigations of Bergenia ligulata Yeo. [PhD Thesis] Punjab University, Chandigarh, India. 1997.
Islam M, Azhar I, Azhar F, Usmanghani K, Gill MA, Ahmad A, Shahabuddin. Evalution of antibacterial activity of Bergenia ciliate, A Pakistan J Pharmaceutical Sci, 15(2), 2002, 21-27.
Panda H, Medicinal plant cultivation and their uses. National Institute of Industrial Research. 2002.
Yadav RD, Jain SK, Shashi Mahor S, Bharti JP, Jaiswal M, Herbal plant used in the treatment of urolithiasis: a review, Int J Pharmaceutical Sci Res, 2(6), 2011, 1412-1420.
Bhandari MR, Anurakkun NJ, Gao H, Kawabata J, α -Glucosidase and α –amylase inhibitory activities of Nepalese medicinal herb Pakhanbhed (Bergenia ciliata, Haw.), Food Chemistry,106, 2008, 247–252.
Polypharmacological activities of Bergenia species: Km.Ruby1, Rajani Chauhan, Swapnil Sharma, Jaya dwivedi Department of Pharmacy, Banasthali University, Tonk, Rajasthan, 304022, India. Department of Chemistry, Banasthali University, Tonk, Rajasthan, 304022, India: Volume 13, Issue 1, March – April 2012; Article-018.
Published
How to Cite
Issue
Section
Copyright (c) 2020 Priyanka Pokhrel, Rishi Ram Parajuli, Amish Kumar Tiwari, Janmajoy Banerjee
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
