Synthesis and characterization of 5-aryl-1,3,4-oxadiazole-2(3h)thione derivatives
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https://doi.org/10.18231/j.joapr.2020.v.8.i.4.50.61Keywords:
1,3,4-oxadiazoles, Syntheses, CharacterizationAbstract
1,3,4-oxadiazoles represent a class of heterocyclic five membered compounds it contain two nitrogen and one oxygen of great importance in Pharmaceutical chemistry. This nucleus show four isomeric forms 1,2,4-oxadiazole,1,3,4-oxadiazole, 1,2,5-oxadiazole, and 1,2,3-oxadiazole. This nucleus has various biological activity such as antioxidant, antimicrobial, antifungal, antitumor, antidepressant, anticancer, analgesic etc. have been reported. A series of 1,3,4-oxadiazoles-2(3H)thione derivative has been synthesized in four steps and the derivative were characterized by FTIR spectral analysis. This article explain the different biological activities associated with 1,3,4-oxadiazole five membered ring are useful for researchers across the world working on this nucleus.
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Saaid FH, Dawood SJ, Marbeen BH. Synthesis and Characterization of 1,3,4- oxadiazole Derivatives using an Ultrasonic Technique. Al-Mustansiriyah Journal of Science, 29(2), 101-105 (2018).
Manjunatha K, Poojari B, Lobo LP, Fernandes J, Kumari N. Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives. European Journal of Medicinal Chemistry, 45(11), 5225-33 (2010)
Bala S, Kamboj S, Kajal A, Saini V. and Prasad DN. 1,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational Studies. Bio Med Research International, 18 (2014)
Roman G, Agache Costel, Manciulea I, Comaniţa E. and Dumitrescu L. Synthesis of new mannich bases derived from 5-phenyl-1,3,4-oxadiazole-2-thione and investigation of the conformational isomers of dimethyl 5-(5-phenyl-2- thioxo-1,3,4-oxadiazole-3-methylamino)isophthalate. Revue Roumaine de Chimie, 52(12), 1103–1110 (2007)
Gilchrist TL. Heterocyclic chemistry, 3th Ed.; Dorling Kindersley(India) Pvt. Ltd., pp. 12-13. (2007)
Kulkarni VS, Lele1 MD, Gavitre BB, Patil MD, Bobe KR. and Gaikwad DT. Oxadiazole: a new profile of biological activities. International Journal of Drug Formulation & Research, 1(3), 134-166 (2010)
Paulo PS, Vitor SS, Marco EFL. 1,2,4- and 1,3,4-Oxadiazoles as Scaffolds in the Development of Antiparasitic Agents. J. Braz. Chem. Soc. 29, 3 (2018)
Shukla C, Srivastava S. Biologically active oxadiazole. Journal of Drug Delivery & Therapeutics. 5(6), 8-13 (2015)
Musmade DS, Pattan SR. and Manjunath SY. Oxadiazole a nucleus with versatile biological behavior. IJPC, 05(01), 11-20 (2015)
Amir M, Shikha K. Synthesis and anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities of some new 2-[(2,6-dichloroanilino)phenyl]acetic acid derivative. Eur. J. Med. Chem., 39, 535-545 (2004)
Aboraia AS, Abdel-Rahman HM, Mahfouz NM, EL-Gendy MA. Novel 5-(2-hydroxyphenyl)-3-substituted-2,3-dihydro-1,3,4-oxadiazole-2-thione derivatives: Promising anticancer agents. Bioorg. Med. Chem., 14, 1236–1246 (2006)
Nagalakshmi G. Synthesis, antimicrobial and antiinflammatory activity of 2,5-disubstituted-1,3,4-oxadiazoles. Indian J Pharm Sci, 70(1), 49-55 (2008)
Dewangan D, Pandey A, Sivakumar T, Rajavel R, Dubey RD. Synthesis of some Novel 2, 5- Disubstituted 1, 3, 4-Oxadiazole and its Analgesic, Anti-Inflammatory, Anti-Bacterial and Anti-Tubercular Activity. Int. J. of Chem Tech Research, 2(3), 1397-1412 (2010)
Ramaprasad GC, Kalluraya B, Kumar BS, Hunnur RK. Synthesis and biological property of some novel 1,3,4-oxadiazoles. Eur. J. Med. Chem., 45, 4587-4593 (2010)
Almasirada A. et al. Synthesis, Anticonvulsant and Muscle Relaxant Activities of Substituted 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole. Acta Chim. Slov. 317(54), 317–324 (2007)
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Copyright (c) 2020 Shailesh Pathak, Sharad Sharma, Vinay Pathak, Mahesh Prasad
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