Syntheses and characterization of 5-aryl-1,3,4-oxadiazole-2(3h)thione derivatives

Authors

  • Shailesh Pathak Kamla Nehru Institute of Management and Technology, Faridipur, Sultanpur, UP
  • Sharad Sharma School Of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan
  • Vinay Pathak Rajarshi Rananjay Singh College of Pharmacy, Amethi , U.P
  • Mahesh Prasad Kamla Nehru Institute of Management and Technology, Faridipur, Sultanpur, U.P

DOI:

https://doi.org/10.18231/j.joapr.2020.v.8.i.4.50.61

Keywords:

1,3,4-oxadiazoles, Syntheses, Characterization

Abstract

1,3,4-oxadiazoles represent a class of heterocyclic five membered compounds it contain two nitrogen and one oxygen of great importance in Pharmaceutical chemistry. This nucleus show four isomeric forms 1,2,4-oxadiazole,1,3,4-oxadiazole, 1,2,5-oxadiazole, and 1,2,3-oxadiazole. This nucleus has various biological activity such as antioxidant, antimicrobial, antifungal, antitumor, antidepressant, anticancer, analgesic etc.  have been reported. A series of 1,3,4-oxadiazoles-2(3H)thione derivative has been synthesized in four steps and the derivative were characterized by FTIR spectral analysis. This article explain the different biological activities associated with 1,3,4-oxadiazole five membered ring are useful for researchers across the world working on this nucleus.

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Published

2020-11-11

How to Cite

Pathak, S., Sharma, S., Pathak, V., & Prasad, M. (2020). Syntheses and characterization of 5-aryl-1,3,4-oxadiazole-2(3h)thione derivatives . Journal of Applied Pharmaceutical Research, 8(4), 50-61. https://doi.org/10.18231/j.joapr.2020.v.8.i.4.50.61

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