Mechanism of haematotoxicity induced by phenylhydrazine: a review

Authors

  • Shwetha B R Mallige College of Pharmacy, Department of Pharmacology, Silvepura, Bangalore-90
  • Siddalingaprasad H S Department of Studies and Research in Biochemistry, Tumkur University, Tumakuru- 572103
  • Shivukumar Swamy Mallige College of Pharmacy, Department of Pharmacology, Silvepura, Bangalore-90
  • Nagalakshmi N C Mallige College of Pharmacy, Department of Pharmacology, Silvepura, Bangalore-90
  • Hariprasad M G Mallige College of Pharmacy, Department of Pharmacology, Silvepura, Bangalore-90

Keywords:

Haemolytic anaemia, Erythropoietin receptors, Phenylhydrazine, Haematotoxicity

Abstract

This work was carried out to show the effects of phenylhydrazine (PHZ) induced anaemic condition. Anaemic condition is defined as reduction in red blood cells (RBC) than normal number of red blood cells. The anti-anaemic activity can be studied using the changes in haematological parameters (PCV, RBC & Haemoglobin) influenced by PHZ [(40mg/kg p.o.)] in rats. PHZ, a potent chemical that causes different effects on different tissues at several levels. Administration of PHZ causes haemolytic anaemia, genotoxic effects and rose in iron absorption in spleen, liver and duodenum & causes change in iron metabolism. PHZ acts by activating immune response which triggers phagocytosis and also interfere with the binding of erythropoietin (EPO) receptors and further JAK-STAT pathway. PHZ also causes genotoxic effect by forming single strand DNA damage. In view of lipid peroxidation along with the formation of Thiobarbituric acid (TBA)-reactive malonyldialdehyde, it is recommend that PHZ induces anaemia as an outcome of peroxidation of  RBC membrane lipids and this effect may be a upshot of the autoxidation of the drug and the interaction of membrane lipids and oxygen radicals

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Published

2019-12-30

How to Cite

Shwetha, B. R., Siddalingaprasad, . H. S., Swamy, S., Nagalakshmi , N. C., & Hariprasad, M. G. (2019). Mechanism of haematotoxicity induced by phenylhydrazine: a review. Journal of Applied Pharmaceutical Research, 7(4), 01-06. Retrieved from https://japtronline.com/index.php/joapr/article/view/112

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