Formulation, optimization and evaluation of quick dispersible tablets of sumatriptan
DOI:
https://doi.org/10.18231/j.joapr.2019.004Keywords:
Quick dispersible, superdisintegrants, sumatriptan succinate, beta-cyclodextrin, aspartameAbstract
The main objective of this study was to prepare quick dispersible tablets of drug sumatriptan succinate, which can rapidly disintegrate in the saliva using three different superdisintegrants that is, sodium starch glycolate, crospovidone, and croscarmallose sodium with taste masking polymer beta-cyclodextrin and aspartame as a sweetener. The taste masking of the drug was done by mixing it with the polymer beta-cyclodextrin using solvent evaporation method and then mixing optimized quantity of aspartame to it. The quick dispersible tablets were prepared by direct compression technique using taste masked drug and other formulation excipients. The effect of various super disintegrants in three different concentrations has been studied. The prepared tablets were evaluated for wetting time, in-vitro disintegration time, strength, and in-vitro dissolution time. As per the results obtained, it was found that the formulation batch no. 4 was found to be the best formulation, as the data’s obtained by it was found to be in the required range of mouth dissolving tablets.
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References
Kolhe S. Formulation and Evaluation of Taste Masked Fast Disintegrating Tablet of Promethazine Hydrochloride. IOSR J. Pharm., 03, 01–11 (2014).
Gryczke A, Schminke S, Maniruzzaman M, Beck J, Douroumis D. Development and evaluation of orally disintegrating tablets (ODTs) containing Ibuprofen granules prepared by hot melt extrusion. Colloids Surfaces B Biointerfaces, 86, 275–84 (2011).
Sano S, Iwao Y, Kimura S, Itai S. Preparation and evaluation of swelling induced-orally disintegrating tablets by microwave irradiation. Int. J. Pharm., 416, 252–9 (2011).
Patel DA, Patel MR, Patel KR, Patel NM. Buccal mucosa as a route for systemic drug delivery: A review. Int. J. Drug Dev. Res., 4, 99–116 (2012).
Hearnden V, Sankar V, Hull K, Juras DV, Greenberg M, Kerr AR, Lockhart PB, Patton LL, Porter S, Thornhill MH. New developments and opportunities in oral mucosal drug delivery for local and systemic disease. Adv. Drug Deliv. Rev., 64, 16–28 (2012).
Bayrak Z, Tas C, Tasdemir U, Erol H, Ozkan CK, Savaser A, Ozkan Y. Formulation of zolmitriptan sublingual tablets prepared by direct compression with different polymers: In vitro and in vivo evaluation. Eur. J. Pharm. Biopharm., 78, 499–505 (2011).
Stoltenberg I, Breitkreutz J. Orally disintegrating mini-tablets (ODMTs) - A novel solid oral dosage form for paediatric use. Eur. J. Pharm. Biopharm., 78, 462–9 (2011).
Gardner D, Lynd L. Sumatriptan and the serotonin syndrome. Ann. Pharmacother., 32, 33–8 (1998).
Bahadur S, Roy A, Sahu DK, Sahu UK, Kumar A, Sonwani R. Formulation and evaluation of oral hypoglycemic tablets utilizing mucilage extracted from plants reportedly having anti diabetic activity. Indo Am. J. Pharm. Sci., 4, 1168–77 (2017).
Bahadur S, Roy A, Baghel P, Chanda R. Formulation of Glipizide Tablets using Fenugreek Seed Mucilage: Optimization by Factorial Design. Asian J. Pharm., 10, S662–8 (2016).
Choudhury A, Das S, Bahadur S, Saha S, Roy A. Formulation and evaluation of omeprazole tablets for duodenal ulcer. Indian J. Pharm. Sci., 72, 491 (2010).
Bahadur S, Roy A, Baghel P, Choudhury A, Saha S, Chanda R. Formulation and evaluation of glipizide tablets utilizing Hibiscus rosasinensis leaves mucilage. Indones. J. Pharm., 29, 23–8 (2018).
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Copyright (c) 2020 Pragya Baghel, Amit Roy, Shashikant Chandrakar, Shashikant Chandrakar, Sanjib Bahadur, Sanjib Bahadur, Monika Bhairam
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