Microsphere: a promising approach for drug delivery
DOI:
https://doi.org/10.18231/j.joapr.2019.001Keywords:
Microsphere, mucoadhesive polymers, novel drug delivery, evaluation of microspheresAbstract
The recent evolution in new drug delivery systems plays a important role in pharmaceutical industries. There are various controlled release products, Microsphere is one among all due to the sustained release and controlled release properties.Microsphere are small spherical shape characteristically free flowing powders, with diameters typically ranging from 1 μm to 1000 μm (1 mm). Microspheres can be produced using several natural and synthetic polymeric materials. Depending on the method, solid or porous microspheres can be obtained for specific intended applications. The variety of methods for the production of microspheres offers numerous opportunities to control the aspects of administration of the API. It provides the prolonged therapeutic action and reduce the dosing frequency, which improve the patient compliance. To get the desired effect the drug should deliver at the target tissue in an ideal amount in the right period of time with maximum therapeutic effect and minimum side effect. Now a day’s microspheres have been used to deliver drugs, vaccines etc. The article is mainly focus on the various aspect of microspheres drug delivery system along with their method of preparation, technique to evaluate its efficiency and pharmaceutical application of microspheres.
Downloads
References
Prasad BS, Gupta VR, Devanna N, Jayasurya K. Microspheres as drug delivery system-a review. J Glob Trends Pharm Sci., 5:1961-72 (2014)
Chintale AG, Kadam VS, Maske KS, Raut DB, Kale SV, Rai SD. recent advances in microsphere drug delivery system: a review. Research Journal of Pharmacy and Technology,1;6(3):X (2013)
Sahil K, Akanksha M, Premjeet S, Bilandi A, Kapoor B. Microsphere: A review. Int. J. Res. Pharm. Chem., 1(4): 1184-98 (2011)
Saini S, Kumar S, Choudhary M, Nitesh, Budhwar V. Microspheres as controlled drug delivery system: an updated review. International Journal of Pharmaceutical Sciences and Research, 1; 9(5):1760-8 (2018)
Kadam NR, Suvarna V. Microsphere: a brief review. Asian Journal Of Biomedical And Pharmaceutical Sciences, 1; 5(47): 13(2015)
Sharma N, Purwar N, Gupta PC. Microspheres as drug carriers for controlled drug delivery: A review. International Journal of Pharmaceutical Sciences And Research; 6(11): 4579(2015).
Midha K, Nagpal M, Arora S. Microspheres: a recent update. Int. J. Recent. Sci. Res., l (8): 5859-67 (2015)
Kumar A, Mahajan S, Bhandari N. Microspheres: a review. World J Pharm Pharm Sci.,14;6:724-40(2017)
Rajput S, Agrawal P, Pathak A, Shrivasatava N, Baghel SS, Baghel RS. A review on microspheres: methods of preparations and evaluation. World Journal Of Pharmacy And Pharmaceutical Sciences, 1:422-38 (2012)
Bansal H, Kaur SP, Gupta AK. Microspheres: methods of preparation and applications: A comparative study. Int J Pharm Sci Rev Res.,10(1):69-78 (2011)
Virmani T, Gupta J. Pharmaceutical application of microspheres: An approach for the treatment of various diseases. Int J Pharm Sci Res., 8:3252-60 (2017)
Srivastava P, Visht S. Application and advancement of microsphere as controlled delivery system: A review. International Journal Of Pharmacy & Life Sciences, 1;4(4) (2013)
Verma NK, Alam G, Vishwakarma DK, Mishra JN, Khan WU, Singh AP, Roshan A. Recent advances in microspheres technology for drug delivery. (2015)
Ganesan P, Johnson AJ, Sabapathy L, Duraikannu A. Review on microsphere. American Journal of Drug Discovery and Development, 4(3):153-79 (2014)
Behera AL, Patil SV, Sahoo SK. Formulation and Characteristics of 5 flurouracil Microspheres by Solvent Evaporation Method. Int J Pharm Pharm Sci., 3(1):32-5 (2011)
Sharma M, Dev SK, Kumar M, Shukla AK. Microspheres as suitable drug carrier in sustained release drug delivery: an overview. Asian Journal of Pharmacy And Pharmacology, 4(2):102-8 (2018)
Ramteke KH, Jadhav VB, Dhole SN. Microspheres: as carriers used for novel drug delivery system. Iosrphr, 2 (4): 44-8 (2012)
Nagoba Shivappa N., Chandrawanshi Mayuri J., Bhalekar Rohini V., Viayjendra Swamy S. M.A Review on Microspheres as a Novel Drug Delivery. System.International Journal Of Pharmacy And Pharmaceutical Research, (2018)
Nerkar PP, Gattani S. In vivo, in vitro evaluation of linseed mucilage based buccal mucoadhesive microspheres of venlafaxine. Drug Delivery,1;18(2):111-21 (2011)
Rajput MS, Agrawal P. Microspheres in cancer therapy. Indian Journal Of Cancer, 1;47(4):458 (2010)
Bahadur S, Roy A, Chanda R, Chouhury A, Das S, Saha S et. al. Natural excipients development: need and future. Asian Journal of Pharmaceutical Research, 4(1): 12 – 15 (2014)
Chanda R, Mahapatro SK, Mitra T, Roy A, Bahadur S. Development of oral mucoadhesive tablets of terbutaline sulphate sing some natural materials extracted from Tamarind indica. Research Journal of Pharmacy and Technology, 1(1): 46-51 (2008)
Bahadur S, Sahu U, Sahu D, Sahu G, Roy A. Review on natural gums and mucilage and their application as excipient. Journal of Applied Pharmaceutical Research, 5 (4): 13 – 21 (2017)
Bahadur S, Chanda R, Roy A, Choudhury A, Das S, Saha S. Preparation and evaluation of mucoadhesive microcapsules of captopril for oral controlled release. Research Journal of Pharmacy and Technology, 1(2): 100 – 105 (2008)
Published
How to Cite
Issue
Section
Copyright (c) 2020 Ananta Choudhury, Debasish Deka, Kashmiri Sonowal, Rahela Eyachmin Laskar
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
