Optimizing novasomes: impact of oleic acid and co-surfactant ratio on posaconazole delivery: In vitro & Ex vivo pharmacokinetic study

Tushar Rukari; Prashant L Pingale; Chandrashekhar D Upasani

doi:10.69857/joapr.v12i3.536

Authors

Tushar Rukari Department of Pharmaceutics, SNJB's Shriman Suresh Dada Jain College of Pharmacy, Chandwad, Maharashtra 423101
Prashant L Pingale Department of Pharmaceutics, M.S. Gosavi College of Pharmaceutical Education and Research, Vidyanagar, College Road, Nashik 422005
Chandrashekhar D Upasani Department of Pharmacology, SNJB's Shriman Suresh Dada Jain College of Pharmacy, Chandwad, Maharashtra 423101, India

DOI:

https://doi.org/10.69857/joapr.v12i3.536

Keywords:

Niosomes, Ufasomes, Span 80, Tween 80, Factorial Design, Design Expert

Abstract

Background: Posaconazole, currently available as a solid oral dosage form, possesses erratic pharmacokinetics that complicate dosing regimens and increase the risk of adverse effects and drug interactions. Hence, innovative strategies, especially topical ones, are necessary to enhance the therapeutic profile and improve patient outcomes. Methodology: The regular 2³ factorial design and the concentrations of Oleic acid: Span 80 (2:1) ratio, Cholesterol, and Tween 80 as independent variables were used for the formulation development. The preliminary effect was determined by dependent variables like vesicle size and entrapment efficiency; then the final optimized batch was loaded in 3 % w/w Carbopol gel. Result and Discussion: The optimized batch's vesicle size and entrapment efficiency were 193.34+14.84 nm and 90.03+0.11 %, respectively. These results were found statistically significant (ANOVA) in the trial version of Stat-Ease 360^®. Other evaluation parameters like zeta potential and pH of all the formulations were also significant (p<0.005). Conclusion: The optimized batch (NF7), when loaded with gel (NF7G-3), showed sustained release of Posaconazole up to 7 h in an In vitro diffusion study facilitated 87.14±0.11 % release confirming non-Fickian or Anomalous diffusion, interpreted from Korsmeyer Peppas (K_KP) model. With the results from In vitro and Ex vivo pharmacokinetic release, the Posaconazole-loaded NF7G-3 Novasomal gel can exhibit potential formulation for the topical treatment of fungal infections. It will help significantly mitigate the negative effects of Posaconazole.

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