Formulation and evaluation of extended release spheroids for antidepressant drug by MUPS

Authors

  • Amrendra Kumar Himalayan Institute of Pharmacy and Research, Dehradun
  • Vikram Singh Himalayan Institute of Pharmacy and Research, Dehradun
  • Divya Juyal Himalayan Institute of Pharmacy and Research, Dehradun
  • Geeta Rawat Department of pharmaceutical sciences, HNB Garhwal Central University), Uttarakhand

Keywords:

Antidepressants, Weight build Up, Thickness, Extended Release

Abstract

The extended release spheroids was Formulated using Ethyl Cellulose, Povidone and Triacetin as a Coating material and evaluated the effect of change in weight build up on drug release profile. Optimization of extended release coating by 19% build up of EC/PVP-K30 of formulation (F4), in which the formulation is formulated by Reservoir system and the drug release depends on coating thickness of EC/PVP-K30. As concentration of coating weight buildup increases. which increases the thickness of coating on the reservoir system hence release retarded and transformed into an extended release system.

Downloads

Download data is not yet available.

References

Kumar S., Das B., Raju S. (2012), Oral Extended Release Drug Delivery System: A Promising Approach, Asian Journal of Pharmacy & Technology Vol. 2: Issue 2, 38-43

Kumar S., Kumar A., Gupta V. et al (2012), Formulation and Evaluation of Multiunit Pellet System of Venlafaxine Hydrochloride, Journal of Pharmaceutical And Biomedical Sciences vol. 18 , 2-3

Ghebre S. (1997), Multiparticulates Oral Drug Delivery, Marcel Dekker Inc, First Edition, 79–355.

Fridrun P. et al, (2009), The influence of non-ionic surfactants on the rheological properties of drug/microcrystalline cellulose/water mixtures and their use in the preparation and drug release performance of pellets prepared by extrusion/ spheronization, European Journal of Pharmaceutical Sciences vol. 37 334-40.

Lieven B. (2009), improved bioavailability of darunavir by use of κ-carrageenan versus microcrystalline celluloseas pelletisation aid, European Journal of Pharmaceutics and Bio pharmaceutics, Vol. 72, 614-20.

Newton J.M. (2002), Factors influencing the physical characteristics of pellets obtained by extrusion and Spheronization, International Journal of Pharmaceutics, Vol. 232 ,91-106.

Published

2014-12-16

How to Cite

Kumar, A., Singh, V., Juyal, D., & Rawat, G. (2014). Formulation and evaluation of extended release spheroids for antidepressant drug by MUPS. Journal of Applied Pharmaceutical Research, 2(4), 24-26. Retrieved from https://japtronline.com/index.php/joapr/article/view/34

Issue

Vol. 2 No. 4 (2014)

Section

Articles

Copyright (c) 2020 Amrendra Kumar, Vikram Singh, Divya Juyal, Geeta Rawat

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.