Formulation and evaluation of extended release spheroids for antidepressant drug by MUPS
Keywords:Antidepressants, Weight build Up, Thickness, Extended Release
The extended release spheroids was Formulated using Ethyl Cellulose, Povidone and Triacetin as a Coating material and evaluated the effect of change in weight build up on drug release profile. Optimization of extended release coating by 19% build up of EC/PVP-K30 of formulation (F4), in which the formulation is formulated by Reservoir system and the drug release depends on coating thickness of EC/PVP-K30. As concentration of coating weight buildup increases. which increases the thickness of coating on the reservoir system hence release retarded and transformed into an extended release system.
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Copyright (c) 2020 Amrendra Kumar, Vikram Singh, Divya Juyal, Geeta Rawat
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