Liposome: a carrier for effective drug delivery

Authors

  • Ananta Choudhury Department of Pharmacy, Assam Down Town University, Panikhaiti, Guwahati, Assam, India Pin- 781026
  • Kashmiri Sonowal Department of Pharmacy, Assam Down Town University, Panikhaiti, Guwahati, Assam, India Pin- 781026
  • Rhela E Laskar Department of Pharmacy, Assam Down Town University, Panikhaiti, Guwahati, Assam, India Pin- 781026
  • Debasish Deka Department of Pharmacy, Assam Down Town University, Panikhaiti, Guwahati, Assam, India Pin- 781026
  • Biplab Kumar Dey Department of Pharmacy, Assam Down Town University, Panikhaiti, Guwahati, Assam, India Pin- 781026

DOI:

https://doi.org/10.18231/j.joapr.2019.v.8.i.1.003

Keywords:

Colloidal drug delivery, liposomes, phospholipid, current status of liposomes

Abstract

Liposomes are the spherical vesicles containing one or more phospholipid bilayer, which was first described in the middle of 60s by Bangham. The bilayer vesicles are considered as an efficient carrier for drug delivery, diagnostic agents, and also an effective tool for vaccine delivery.  Liposome has been used as a potential carrier for several diseases from cardiovascular disease to bacterial infection and also it has the ability to reducing the toxicity of highly potent drugs and simultaneously utilized to improve pharmacokinetics and therapeutic efficacy. A liposome is a formulation which has the capacity to overcome with the limitation of conventional therapies. For the delivery of liposome ocular and inhalation route are some advanced technology. In poorly water soluble substance pulmonary delivery is very much useful. However liposome based vaccines have been demonstrated in clinical trials and further progress in human trails. This review discusses the mechanism of action, Method of preparation, evaluation, application of liposomal drug delivery system along with the recent developments some of the commercially available products.

Downloads

Download data is not yet available.

References

Zylberberg C, Matosevic S. Pharmaceutical Liposomal Drug Delivery: A Review Of New Delivery Systems And A Look At The Regulatory Landscape. Drug Delivery, 23, 3319-3329 (2016)

Torchilin VP. Liposomes As Pharmaceutical Carriers. Nature Reviews/Drug Discovery, 4, 145-160(2005)

Maheswaran1 A, Brindha P,.Mullaicharam AR , Masilamani K. Liposomal Drug Delivery Systems – A Review. International Journal Of Pharmaceutical Sciences Review And Research, 55, 295-301 (2013)

Roy AS, Das SU, Samanta AR. Design Formulation And Evaluation Of Liposome Containing Isoniazid. Int. J. App Pharm,10, 52-56 (2018)

Li J, Wang X, Zhang T, Wang C, Huang Z, Luo X, Deng Y. A Review On Phospholipids And Their Main Applications In Drug Delivery Systems. Asian Journal Of Pharmaceutical Sciences,10, 81-98 (2015)

Kalepu S, Sunilkumar KT, Betha S, Mohanvarma M. Liposomal Drug Delivery System A Comprehensive Review. Int J Drug Dev Res,5, 62-75 (2013)

Kant S, Kumar S, Prashar B. A Complete Review On Liposome. International Research Journal Of Pharmacy,3, 2230-8407 (2012)

Goswami P, Changmai A, Barakoti H, Choudhury A, Kumar D B. A Brief Review On Liposomal Drug Delivery System. Journal Of Pharmaceutical Advanced Research,1, 362-368 (2018)

Laouini A, Jaafar-Maalej C, Limayem-Blouza I, Sfar S, Charcosset C, Fessi H. Preparation Characterization And Applications Of Liposomes: State Of The Art. Journal Of Colloid Science And Biotechnology,1, 147-168 (2012)

Mansoori MA, Agrawal S, Jawade S, Khan MI. A Review On Liposome. IJARPB,2, 453-464 (2012)

Samad A, Sultana Y, Aqil M. Liposomal Drug Delivery Systems: An Update Review. Current Drug Delivery, 4, 297-305 (2007)

Akbarzadeh A, Sadabady RR, Davaran S, Joo WS, Zarghami N, Hanifehpour Y, Samiei M, Kouhi M, Koshki NK. Liposome: Classification, Preparation, And Applications. Nanoscale Research Letters, 8, 102 (2013)

Dua JS, Rana AC, Bhandari AK. Liposome: Methods Of Preparation And Applications. Int J Pharm Stud Res,3, 14-20 (2012)

Andhale VA, Patil PR, Dhas AU, Chauhan PD, Desai SV. Liposome: An Emerging Tool In Drug Carrier System. Int J Pharmacy Technol, 8, 10982-11011 (2016)

Patel RP, Patel H, Baria AH. Formulation And Evaluation Of Liposomes Of Ketoconazole. Int J Drug Deliv Technol, 21, 16-23 (2009)

Sercombe L, Veerati T, Moheimani F, Sherry YW, Sood AK, Hua1 S. Advances And Challenges Of Liposome Assisted Drug Delivery. Front Pharmacol,6, 1-13 (2015)

Kulkarni PR, Yadav JD, Vaidya KA. Liposomes: A Novel Drug Delivery System. International Journal Of Current Pharmaceutical Research, 3, 10-18 (2011)

Giuseppina B, Agnese M. Liposomes As Nanomedical Devices. International Journal Of Nanomedicine,10, 975- 999 (2015)

Saha S, Roy A, Bahadur S, Choudhury A. Fabrication and in-vitro evaluation of liposomal quercetin and its optimization. Research Journal of Pharmacy and Technology, 11(1), 61 – 64 (2018)

Roy A, Saha S, Choudhury A, Bahadur S. Bioenhancement of curcumin by combined approaches of adjuvants and liposomal fabrication. Asian Journal of Pharmaceutics, 10(4), S688 – S692 (2016)

Saini A. A Platform For Liposomal Drug Delivery. Int J Pharm Drug Anal, 3, 6-11 (2015)

Daraee H, Etemadi A, Kouhi M, Alimirzalu S, Akbarzadeh A. Application Of Liposomes In Medicine And Drug Delivery. Artificial Cells, Nanomedicine, And Biotechnology, 44, 381-91 (2016)

Published

2020-03-30

How to Cite

Choudhury, A., Sonowal, K., Laskar, R. E., Deka, D., & Dey, B. K. (2020). Liposome: a carrier for effective drug delivery. Journal of Applied Pharmaceutical Research, 8(1), 22-28. https://doi.org/10.18231/j.joapr.2019.v.8.i.1.003

Issue

Vol. 8 No. 1 (2020)

Section

Articles

Copyright (c) 2020 Ananta Choudhury, Kashmiri Sonowal, Suman Saha, Biplab Kumar Dey

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Crossref
Scopus
Google Scholar
Europe PMC