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Investigation of anti-hyperglycemic and antibacterial activity of the fruit extract of Calamus tenuis was carried out. Soxhlet extraction was done using petroleum ether, ethyl acetate and methanol. Anti-hyperglycemic activity was done by Oral Glucose Tolerance Test. The results indicated that methanol extract showed nearly same potency of blood glucose lowering capacity with a dose of 500 mg/Kg (4.82 ± 0.730 mmol/L) compared to the glibenclamide (standard drug) produced (4.26 ± 0.441 mmol/L) at 5 mg/Kg dose after 120 min of glucose feeding to mice. Antibacterial activity was investigated using disc diffusion method. Antibacterial tests revealed that S. aureus was resistant to all the solvent extracts. Ethyl acetate and methanol extracts showed moderate antibacterial capacity against both Micrococcus and V. cholerea whereas petroleum ether showed nothing. Zone of inhibition of Ethyl acetate and methanol extracts (200 mg/mL dose) for E. coli were very close to positive control (17.00 ± 0.816 and 18.75 ± 1.258 mm respectively; positive control value was 19.00 ± 1.414 and 21.00 ± 1.414 respectively ). In case of methanol zone of inhibitions were greater than other solvent extracts against all tested bacterial species. From this study it can be concluded that the C. tenuis fruit may serve as a new potential source of medicines due to the presence of biological activity.
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 Elujoba AA, Odeleye OM, Ogunyemi CM. Traditional medicine development for medical and dental primary health care delivery system in Africa. African Journal of Traditional, Complementary and Alternative Medicine, 2, 46-61 (2005).
 Tomlinson TR, Akerele O. Medicinal plants: their role in health and biodiversity. University of Pennsylvania Press, Philadelphia, 11-41 (1998).
 Durst PB, Ulrich W, Kashio M. Non-wood forest products in Asia. Bangkok; Rapa Publication (1994).
 Manohara TN. Nutritional Evaluation of Shoots of Two Rattans of Northeast India- Calamus flagellum Griff. Ex Mart. and C. floribundus Griff. (Arecaceae). Econ Bot, 67(3), 263–268 (2013).
 Dransfield J, Tesoro FO, Manokaran N. Rattan: current research issues and prospects for conservation and sustainable development. Rome; FAO (2002).
 Ahmed ZU, Bithi SS, Khan MR, Hossain M, Sharmin S, Rony SR. Phytochemical screening, antioxidant and cytotoxic activity of fruit extracts of Calamus tenuis Roxb. J Coastal Life Med, 2(8), 645-650 (2014).
 Hossain MS. Analgesic and Neuropharmacological activity of methanolic extract of Calamus tenuis Roxb. Fruits. J Sci Innovative Res, 2(6), 1067-1072 (2013).
 Khare CP. Indian medicinal plants: an illustrated dictionary. Springer Science & Business Media (2007).
 Yu GF, Mulabagal V, Diyabalanage T, Hurtada WA , DeWitt DL, Nair MG. Nonnutritive functional agents in rattan-shoots, a food consumed by native people in the Philippines. Food Chem, 110, 991–996 (2008).
 Tag H, Kalita P, Dwivedi P, Das AK, Namsa ND. Herbal medicines used in the treatment of diabetes mellitus in Arunachal Himalaya, northeast, India. J Ethnophmacol, 141(3), 786-95 (2012).
 Saikia P, Khan ML. Diversity of Medicinal Plants and their uses in home gardens of upper Assam, Northeast India. Asian J Pharm Biol Res, 1(3), 296-309 (2011).
 Joy KL, Kuttan R. Anti-diabetic activity of Picrorrhiza kurroa extract. J Ethnopharmacol, 67(2), 143-48 (1999).
 Bauer AW, Kirby WM, Sherries JC, Truck M. Antibacterial susceptibility testing by a standardized single disk method. American Journal of Clinical Pathology, 45, 493-496 (1966).
 Eddouks M, Maghrani M. Effect of Lepidium sativum L. on Renal Glucose Reabsorption and Urinary TGF-β1 Levels in Diabetic Rats. Phytother. Res, 22, 1–5 (2008).
 Dalu D, Duggirala S, Akarapu S. Anti hyperglycemic and hypolipidemic activity of leea indica. Int. J. Bioassays, 3 (07), 3155-3159 (2014).
 Ghosh A, Banik S, Amin MN, Ahmed J. Evaluation of antinociceptive, antihyperglycemic, and membrane stabilizing activities of Garcinia lancifolia Roxb. Journal of Traditional and Complementary Medicine xxx, 1-5 (2017).
 Maniyar Y, Bhixavatimath P, Agashikar NV. Antidiarrheal activity of flowers of Ixora Coccinea Linn. in rats. J Ayurveda Integr Med, 1, 287-291 (2010).
 Muroi, H, Kubo I. Antibacterial activity of anacardic acids and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus. J. Appl. Bacteriol, 80, 387-394 (1996).
 Halvorsen BL, Carlsen MH, Phillips KM, Bohn SK, Holte K, Jacobs DR Jr, Blomhoff R. Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States. Am J Clin Nutr, 84, 95-135 (2006).
 Chopra PKPG, Saraf BD, Inam S, Deo SS. Antimicrobial and antioxidant activities of methanol extract roots of Glycyrrhiza glabra and HPLC analysis. Int. J. Pharm. Pharm. Sci., 5(2), 157-160 (2013).