A review on mouth dissolving tablet

Main Article Content

Harshal Kailash Patil G. M. Patil V. H. Jain S. A. Tadvi S. P. Pawar

Abstract

The demand for MDT (Mouth Disintegrating Tablet) has been increasing from the last decade particularly in geriatric, pediatric and patient with some sort of disabilities in swallowing. MDTs are those tablets which when placed in mouth get dissolved rapidly in saliva without the need of liquid and can be swallowed. European pharmacopoeia adopted the term Orodispersible tablet for MDTs. Mouth disintegrating tablets are also known as Fast melting tablets, Orodispersible tablets, fast dissolving/dispersing tablets or melt in mouth tablets. This article reviews the potential benefits offered by MDTs as an oral drug delivery system for various kinds of patients suffering from different diseases and disabilities. Desired characteristics and challenges for developing fast disintegrating drug delivery systems, quality control tests, various techniques used in the preparation of fast disintegrating drug delivery systems like lyophilization technologies, tablet molding method, sublimation techniques, spray drying techniques, mass extrusion technology, direct compression method and uses of super-disintegrates. It also reviews the patented technologies for fast dissolving tablets, advantages and disadvantages of different technologies for preparing fast disintegrating dosage form, future prospective for MDTs. The growing importance for MDTs is due to the potential advantages offered by this technology. MDT is a New Drug Delivery system with least disintegration time and ease of self administration

Article Details

How to Cite
PATIL, Harshal Kailash et al. A review on mouth dissolving tablet. Journal of Applied Pharmaceutical Research, [S.l.], v. 5, n. 2, p. 09-15, apr. 2017. ISSN 2348-0335. Available at: <http://japtronline.com/index.php/JOAPR/article/view/102>. Date accessed: 17 aug. 2017.
Keywords
MDT; Orodispersible tablets; fast dissolving; dispersing tablets; Melt in mouth tablets; Mass extrusion; Superdisintegrants
Section
Articles

References

[1] Modasiya M, Lala I, Prajapati B, Patel V, Shah D. Design and characterization of Fast Disintegrating Tablets of Piroxicam. International Journal of PharmaTech Research, 2(1), 353-357 (2009).
[2] Sahoo S, Mishra B, Biswal P, Panda O, Mahapatra S, Jana G. Fast Dissolving Tablet: As A Potential Drug Delivery System. Drug Invention, 2(2), 130-135 (2010).
[3] Kaur T, Gill B, Kumar S, Gupta G. Mouth Dissolving Tablets: A Novel Approach to Drug Delivery. International Journal of Current Pharmaceutical Research, 3(1), 1-7 (2011).
[4] Nayak U, Patra S, Rout P, Patro B, Nayak B. Development and optimization of prometazine theoclate Mouth dissolving tabltes. The Indian Pharmacist, 4, 65-68 (2008).
[5] Reddy L, Ghosh B, Rajneesh R. Fast Dissolving Drug Delivery system: A review of the literature. Indian Journal of Pharmaceutical Sciences, 64(4), 1-3 (2002).
[6] Kuchekar B, Arumungam V. Fast Dissolving Drug Delivery System. Indian Journal of pharmaceuticals and research education, 35, 150-155 (2001).
[7] Bhushan Y, Sambhaji S, Anant R, Kakasaheb R. New drug delivery system for elderly. Indian Drugs, 37, 312-318 (2000).
[8] Gregory G, Ho D, U.S.Patent 4, 305,502 (1981).
[9] Koizumi K. New Method of Preparing high porosity rapid saliva soluble compressed tablet using mannitol with camphour, a subliming material. International Journal of Pharmaceutics, 152(1), 127-131 (1997).
[10] Allen V, Wang B, U.S. Patent U55587180 (1996).
[11] Gupta A, Mittal A, Jha K. Fast Dissolving Tablet- A Review. The Pharma Innovation, 1, 1-8 (2012).
[12] Panigrahi R, Behera S. A Review on Fast Dissolving Tablets. Webmed Central Quality and patient safety, 9, 1-15 (2010).
[13] Mishra U, Prajapatil S, Bharadvaj P. A Review Article on Mouth Dissolving Tablet. International Journal of Pharma Research & Review, 3(6), 24-34 (2014).
[14] Indian Pharmacopoeia. Controller of Publications. 4th edition, Volume 2, New Delhi, pp735-736; 1996.
[15] Abdul S, Mohammad H. Mouth dissolving tablets: An overview. International Journal of Research in Pharmaceutical and Biomedical Sciences, 2(3), 959-970 (2011).